Nicotine replacement therapy: evidence from observational studies versus clinical trials

Johnson George
Med J Aust 2012; 197 (1): 28. || doi: 10.5694/mja12.10653
Published online: 2 July 2012
  • Johnson George

  • Centre for Medicine Use and Safety, Monash University, Parkville, VIC.


Competing interests:

I am an investigator in the Give Up For Good clinical trial, evaluating a multidisciplinary smoking intervention initiated during hospital stay, funded by the Australian Research Council and an investigator-initiated research grant from Pfizer.

  • 1. Alpert HR, Connolly GN, Biener L. A prospective cohort study challenging the effectiveness of population-based medical intervention for smoking cessation. Tob Control 2012. doi: 10.1136/tobaccocontrol-2011-050129.
  • 2. Stead LF, Perera R, Bullen C, et al. Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev 2008; (1): CD000146.
  • 3. Moore D, Aveyard P, Connock M, et al. Effectiveness and safety of nicotine replacement therapy assisted reduction to stop smoking: systematic review and meta-analysis. BMJ 2009; 338: b1024.
  • 4. Pierce JP, Gilpin EA. Impact of over-the-counter sales on effectiveness of pharmaceutical aids for smoking cessation. JAMA 2002; 288: 1260-1264.
  • 5. Alberg AJ, Patnaik JL, May JW, et al. Nicotine replacement therapy use among a cohort of smokers. J Addict Dis 2005; 24: 101-113.


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