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Is it appropriate to treat people at high-risk of psychosis before first onset? — No

David J Castle
Med J Aust 2012; 196 (9): 557.
doi:
10.5694/mja12.10669

Schizophrenia expert David Castle suggests caution, especially regarding medication use

David J Castle, MD, FRANZCP, FRCPsych, Professor of Psychiatry
St Vincent's Hospital, Melbourne, VIC.
Article References: 
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Fusar-Poli P, Bonoldi I, Yung AR, et al. Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk. Arch Gen Psychiatry 2012; 69: 220-229.
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Carr V. Time to move on? Commentary on the early intervention in psychosis debate. ANZ J Psychiatry 2012; 46: 384-386.
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Morrison AP, French P, Stewart SLK, et al. Early detection and intervention evaluation for people at risk of psychosis: multisite randomised controlled trial. BMJ 2012; 344: e2233. doi: 10.1136/bmj.e2233.
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Bechdolf A, Wagner M, Ruhrmann S, et al. Preventing progression to first-episode psychosis in early initial prodromal states. Br J Psychiatry 2012; 200: 22-29.
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5
PubMed ID: 
22075649

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