A population-based study of thrombolysis for acute stroke in South Australia

Tim Kleinig, James M Leyden, Andrew Lee and Jim Jannes
Med J Aust 2011; 194 (8): . || doi: 10.5694/j.1326-5377.2011.tb03050.x
Published online: 18 April 2011

In reply: To a carpenter, everything looks like a nail, and to a stroke thrombolysis sceptic, every study seems to confirm their opinion. A result cannot be “clinically important” yet statistically not so. We found no difference in symptomatic intracranial haemorrhage rates between our study and others using the same definition. The most widely accepted estimates of the true number needed to harm (for functional outcome at 3 months, following treatment within 3 hours) is about 30, as opposed to a number needed to benefit of around three.1

  • Tim Kleinig1
  • James M Leyden2
  • Andrew Lee3
  • Jim Jannes2

  • 1 Royal Adelaide Hospital, Adelaide, SA.
  • 2 Queen Elizabeth Hospital, Adelaide, SA.
  • 3 Comprehensive Stroke Centre, Flinders Medical Centre, Adelaide, SA.


remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.