Thiamine (vitamin B1) concentrations in a population of Australians with alcohol use disorders are remarkably elevated

Philip M Crowley and Matt D Gaughwin
Med J Aust 2011; 194 (5): . || doi: 10.5694/j.1326-5377.2011.tb02966.x
Published online: 7 March 2011

To the Editor: In Australia, addition of thiamine to bread flour (at 6.4 mg/kg) was made mandatory on 1 January 1991 in an effort to reduce the incidence of Wernicke’s encephalopathy and Korsakoff psychosis.1 Recently, an isocratic high-performance liquid chromatography (HPLC) method for the assessment of thiamine, thiamine monophosphate and thiamine diphosphate (TDP) in human erythrocytes has been described.2 This direct method of measuring thiamine in blood is superior to measuring red blood cell transketolase.

  • Philip M Crowley
  • Matt D Gaughwin

  • Drug and Alcohol Services South Australia, Adelaide, SA.


We thank the staff and clients of the Driver Assessment Clinic, Drug and Alcohol Services South Australia.


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