AS HEAD of the Unit on Vulnerable Populations, Department of Bioethics, NIH Clinical Center, in the United States, David Wendler continues to contribute to the rich debate on issues surrounding ethical research involving vulnerable populations, including children, who cannot give informed consent. This particular work was written while Wendler was a Faculty Fellow in Ethics at the Safra Center for Ethics at Harvard University, and is the result of over 10 years of research. A balanced and engaging analysis of the justifications for the ethical acceptability of non-beneficial paediatric research is critical, if we are to undertake ethically sound translational research in vulnerable populations to improve medical care.
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