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The impact of obesity on weight change and outcomes at 12 months in patients undergoing total hip arthroplasty

Michelle M Dowsey, Danny Liew, James D Stoney and Peter F M Choong
Med J Aust 2010; 193 (1): 17-21. || doi: 10.5694/j.1326-5377.2010.tb03734.x
Published online: 5 July 2010

Abstract

Objectives: To establish the rate of clinically significant weight change after 12 months in patients who have had a primary total hip arthroplasty (THA); to identify patient characteristics that predicted weight loss or gain; and to compare clinical and functional outcomes between obese and non-obese patients.

Design, setting and participants: Prospective study of 471 patients who underwent THA between 2006 and 2007 at St Vincent’s Hospital, Melbourne, a university-affiliated tertiary referral centre. Patients were classified as non-obese, obese and morbidly obese, and were assessed using the Harris Hip Score (HHS) and 12-item Short Form Health Survey (SF-12).

Main outcome measures: Incidence of weight loss or gain 12 months after surgery; preoperative patient variables predictive of weight change; functional and quality-of-life outcomes and rate of adverse events at 12 months; differences in outcomes between obese and non-obese patients.

Results: 194 patients (41%) were obese or morbidly obese. At 12-month follow-up, 18 obese or morbidly obese patients (9%) had lost ≥ 5% of their preoperative weight and 118 patients (25%) had gained ≥ 5% of their preoperative weight. No preoperative predictor of weight loss was identified, but weight gain was associated with lower preoperative SF-12 mental health scores (odds ratio [OR], 0.98 [95% CI, 0.96–0.99]; P = 0.04). There were no significant differences between obesity groups in improvement in HHS or SF-12 physical health scores. Improvement in SF-12 mental health scores was greater in obese (+ 3.6 [SD, 12.2]) and morbidly obese (+ 3.7 [SD, 9.4]) patients than in non-obese patients (– 0.1 [SD, 11.7]) (P = 0.01). Compared with non-obese patients, the odds of a postoperative complication were significantly greater in obese patients (OR, 1.81 [95% CI, 1.05–3.11]) and morbidly obese patients (OR, 5.77 [95% CI, 2.10-15.86]).

Conclusion: Clinically significant weight loss in obese patients after THA is uncommon. Obese and morbidly obese patients experience comparable reduction in pain and improvement in function after THA, but the risk of complications in the first 12 months after surgery is significantly greater than the risk in non-obese patients.

Currently, in Australia, osteoarthritis accounts for a significant portion of the morbidity burden (4.8% of total years of life lived with disability), third only to depression (8.0%) and dementia (5.6%).1 Fifteen per cent of the Australian population is afflicted with osteoarthritis.2 Total joint arthroplasty is the treatment of choice (among suitably “fit” candidates) for end-stage osteoarthritis,3 given its effectiveness in relieving pain and restoring function.4-6

Obesity is over-represented in patients presenting for total hip arthroplasty (THA).7,8 However, little is known about the impact of obesity on postoperative outcomes and weight change. Results of current research on the impact of obesity on functional and quality-of-life (QOL) outcomes after THA are equivocal — possibly due, in part, to significant variation in study methodologies.9-12 Studies that have examined weight change after THA consistently report that most obese patients do not lose weight after the procedure.13-17 What is yet to be investigated is whether certain patient characteristics are predictive of weight change after hip replacement. Knowing this would enable health professionals to identify patients who are unlikely to lose weight and to accurately target such patients for appropriate intervention. With this in mind, the primary aims of our study were to establish the rate of clinically significant weight change after 12 months in patients who have had primary THA and to identify patient characteristics that predicted weight loss or gain. A secondary aim was to compare clinical and functional outcomes between obese and non-obese patients.

Methods
Health questionnaires

Functional assessment was monitored using the Harris Hip Score (HHS) for hip arthroplasty, a validated scoring system for hip function.19 The maximum score for the HHS is 100 points, with maximum possible scores for its component parts as follows: pain (44), function (47), range of motion (5) and deformity (4).20 (A higher HHS score indicates better function.) Physical and mental health were assessed using the 12-item Short Form Health Survey (SF-12), a validated measure of QOL in joint replacement.21 The SF-12 has physical health (Physical Component Summary [PCS]) and mental health (Mental Component Summary [MCS]) scores, with maximum scores (56.58 for PCS and 60.76 for MCS) based on population norms. (A lower SF-12 score indicates poorer physical and/or mental health.)

Obesity definitions

World Health Organization definitions were used to classify patients into obesity categories.22 Patients with a body mass index (BMI) < 30 kg/m2 were defined as non-obese, those with BMI 30–39 kg/m2 as obese, and those with BMI ≥ 40kg/m2 as morbidly obese.

Results

A total of 511 primary THAs were performed on 480 patients during the study period. Nine patients were excluded from the analysis because informed consent was not obtained (n = 5) or the operation involved hip resurfacing (n = 4). No simultaneous bilateral procedures were performed during the study period. For the 31 patients who underwent staged bilateral hip replacement, only the second procedure was included in our analysis. There were six deaths before the 12-month review, and one patient did not complete the health questionnaires. Thus 464/471 patients (98.5%) completed the functional and QOL assessment.

Of the 471 patients, 286 (60.7%) were women and 259 (55.0%) had procedures on the right hip. The mean age of patients was 68.9 years (SD, 10.4 years), and the mean BMI was 29.5 kg/m2 (SD, 5.6 kg/m2). Of the total group, 277 (58.8%) were non-obese, 173 (36.7%) obese and 21 (4.5%) morbidly obese. Demographic and surgical data for each weight group are summarised in Box 1. Significantly more women were obese. The number of total comorbidities and proportions of patients with cardiovascular comorbidities and diabetes were higher in the obese and morbidly obese groups than in the non-obese group. Length of stay in hospital was significantly greater in morbidly obese patients.

Discussion

Our study of a consecutive series of patients undergoing primary THA over a 2-year period found that the majority of obese patients did not lose weight in the first 12 months after surgery. Indeed, one in four patients gained weight. No individual patient characteristic predicted weight loss. However, weight gain was associated with poorer preoperative mental health scores. Improvements in function and QOL after surgery were comparable between non-obese and obese groups, but obese and morbidly obese patients incurred a significantly greater risk of complications. The risk of complications in the first 12 months after THA increased by 7% for each unit increase in BMI, after adjusting for age and sex.

Although a number of small studies have reported that patients tend to gain an average of 2%–3% of their preoperative weight after THA,15,17,26 only one provided data on the number of patients who lost weight after surgery.13 However, weight loss was not quantified and predictive patient characteristics were not investigated.

Despite significant reduction in pain and improvement in function reported in obese and morbidly obese patients after surgery, the incidence of weight loss was relatively low. Functional ability is only one of a number of factors that affect a person’s willingness to participate in physical activity (and thus aid weight loss) after surgery. Several variables not recorded in our study have been found to be associated with motivation to participate in physical activity, including cost, accessibility, knowledge, cultural influences, socioeconomic status and self-efficacy.27-29 Poorer mental health may present another barrier to participation in physical activity, given the association with weight gain demonstrated in our study.

Previous cohort studies investigating functional and QOL outcomes in obese patients have been limited by the use of datasets that have excluded up to three-quarters of patients because of incomplete data.12 The level of patient follow-up has also been identified as a limiting factor.9 Despite this, the findings of such studies have been similar to our findings, in that comparable gains in function and QOL were experienced in non-obese and obese groups after THA. There have also been a number of studies, in contrast to ours,11,30,31 reporting poorer functional and QOL outcomes in obese groups. However, inconsistency between studies in the health questionnaires that were used limits the validity of comparing their results.21,32

No single complication was significantly associated with obesity, but the risk of incurring any type of complication rose significantly as BMI increased. Despite the small number of morbidly obese patients in our study, a significantly higher complication rate (nearly sixfold that of non-obese patients) was detected in this group. As in our study, others have reported relatively small numbers of morbidly obese patients, yet still demonstrated an association with higher rates of complications, such as prolonged wound drainage,33 higher dislocation rates34 and higher rates of prosthetic infection.35

Major strengths of our study were its overall sample size and the completeness of recruitment and follow-up. However, the sourcing of patients from a single centre was a potential source of selection bias. Although there are very few studies with which ours can be compared, we note that the proportion of obese patients in our study was double that of another large Australian study of patients undergoing THA.36 The age and sex ratios of our cohort were similar to those of major arthroplasty centres throughout Australia.37

Two other limitations also warrant mention. First, because our study did not include a non-THA control group, we were unable to compare weight change in our patients with weight change in untreated patients. Secondly, our study was limited by the relatively small number of morbidly obese patients (n = 21). Although analyses of complication outcomes were adequately powered, analyses of health scores may not have been. The small subgroup of morbidly obese patients may have also affected our weight change analysis. Using percentage weight change rather than absolute weight may disadvantage morbidly obese patients, who would need to shed more weight after surgery in order to demonstrate a 5% shift. However, our study was concerned with clinically significant weight loss and providing a meaningful definition for clinicians. As such, we were guided by the US Food and Drug Administration,23 the Dietitians Association of Australia24 and other experts,38 who report that 5%–10% weight loss can produce significant improvement in cardiovascular and metabolic health.

Despite the low level of weight loss after THA and a significantly greater risk of complications among obese and morbidly obese patients, clinicians can inform their patients that they are likely to experience significant reduction in pain and improvement in function after surgery. Before consenting to surgery, obese patients should be counselled about the high risk of adverse events. But given the disabling effects of end-stage osteoarthritis — continued functional decline, worsening health and loss of independence — many patients are likely to opt for surgery despite the risk. Interventions targeting weight loss and health improvement in obese patients undergoing THA are yet to be tested, and this should be the focus of future research.

1 Demographics and operative details*

Variable

Non-obese (n = 277)

Obese (n = 173)

Morbidly obese (n = 21)

P


Mean BMI (kg/m2) (SD)

25.8 (2.9)

33.9 (2.8)

43.3 (3.0)

Mean age (years) (SD)

68.6 (10.8)

67.0 (9.7)

65.6 (10.7)

0.18

Sex

0.04

Male (n = 185)

116 (63%)

66 (36%)

3 (2%)

Female (n = 286)

161 (56%)

107 (37%)

18 (6%)

Aetiology

0.70

Osteoarthritis

230 (58%)

148 (37%)

18 (5%)

Rheumatoid arthritis

9 (47%)

8 (42%)

2 (11%)

Necrosis

24 (67%)

11 (31%)

1 (3%)

Congenital dysplasia of the hip

14 (70%)

6 (30%)

0

Charnley classification

0.39

A

258 (60%)

158 (36%)

17 (4%)

B

10 (53%)

7 (37%)

2 (11%)

C

9 (47%)

8 (42%)

2 (11%)

Mean number of comorbidities (SD)

2.3 (1.6)

2.8 (1.7)

2.8 (1.2)

< 0.01

Type of comorbity§

Cardiovascular

155 (56%)

123 (71%)

15 (71%)

< 0.01

Diabetes

27 (10%)

35 (20%)

6 (29%)

< 0.01

Respiratory

42 (15%)

33 (19%)

5 (24%)

0.39

Cementation of prosthesis

0.34

Uncemented

56 (54%)

44 (42%)

4 (4%)

Hybrid

192 (60%)

111 (35%)

17 (5%)

Fully cemented

29 (62%)

18 (38%)

0

Length of stay (days) (SD)

6.0 (2.2)

6.1 (1.7)

7.7 (7.8)

0.01

Discharge

0.85

To home

209 (59%)

131 (37%)

15 (4%)

To rehabilitation

68 (59%)

42 (36%)

6 (5%)


BMI = body mass index. * Data are number (%), except where otherwise specified. Reference group. Denotes which comparison group differed significantly from reference group. § Percentages relate to the proportion of patients in each weight category who had the specified comorbidity. For example, 155/277 non-obese patients (56%) had a cardiovascular comorbidity; 123/173 obese patients (71%) had a cardiovascular comorbidity (some patients had more than one type of comorbity).

3 Functional and quality-of-life scores*

Score

Non-obese

Obese

Morbidly obese

P


Pain score

Preadmission

11.9 (4.4)

11.8 (4.0)

11.0 (3.0)

0.64

At 12 months

38.4 (9.4)

39.1 (8.7)

37.5 (10.6)

0.64

Change

+ 26.5 (10.2)

+ 27.3 (9.2)

+ 26.6 (11.5)

0.71

Function score

Preadmission

18.0 (9.2)

16.9 (8.7)

13.4 (9.0)§

0.05

At 12 months

34.2 (10.9)

32.5 (10.8)

24.9 (11.5)§

< 0.01

Change

+ 16.2 (11.4)

+ 15.6 (10.2)

+ 11.5 (8.2)

0.16

Total score

Preadmission

36.6 (11.4)

35.4 (10.7)

30.2 (8.9)§

0.03

At 12 months

80.8 (16.9)

79.8 (17.0)

70.5 (18.8)§

0.03

Change

+ 44.1 (18.0)

+ 44.1 (16.8)

+ 40.3 (18.3)

0.63

PCS

Preadmission

25.7 (5.6)

25.3 (4.5)

22.9 (3.6)

0.05

At 12 months

40.0 (11.4)

37.5 (11.0)§

33.6 (10.2)§

0.01

Change

+ 14.3 (11.2)

+ 12.2 (11.8)

+ 10.7 (10.3)

0.09

MCS

Preadmission

50.8 (9.8)

46.9 (10.4)§

47.2 (10.3)

< 0.01

At 12 months

50.7 (11.8)

50.5 (10.5)

50.9 (9.7)

0.98

Change

– 0.1 (11.7)

+ 3.6 (12.2)§

+ 3.7 (9.4)

0.01


MCS = Mental Component Summary. PCS = Physical Component Summary. * Data are mean score (SD). Reference group. Pain score (maximum 44 points) and function score (maximum 47 points) are components of the Harris Hip Score (HHS). The maximum HHS score (100 points) indicates no functional impairment. § Denotes which comparison group(s) differed significantly from reference group. PCS and MCS are components of the 12-item Short Form Health Survey (SF-12). Population norms are 56.58 for PCS and 60.76 for MCS (a person can score higher than the population norm). A lower SF-12 score indicates poorer physical and/or mental health.

Received 28 July 2009, accepted 18 January 2010

  • Michelle M Dowsey1
  • Danny Liew2
  • James D Stoney1
  • Peter F M Choong1,3

  • 1 Department of Orthopaedics, St Vincent's Hospital, Melbourne, VIC.
  • 2 Department of Medicine, University of Melbourne, Melbourne, VIC.
  • 3 Department of Surgery, University of Melbourne, Melbourne, VIC.


Correspondence: pchoong@unimelb.edu.au

Acknowledgements: 

Michelle Dowsey is supported by a National Health and Medical Research Council postgraduate scholarship in public health. We would like to thank Eleanor Nemiro and Ceara Howley for assisting with data collection and recording the anthropomorphic measurements.

Competing interests:

None identified.

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