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Vertebroplasty appears no better than placebo for painful osteoporotic spinal fractures, and has potential to cause harm
Rachelle Buchbinder, Richard H Osborne and David Kallmes
Med J Aust 2010; 192 (3): 174-175.
Rachelle Buchbinder, NHMRC Practitioner Fellow, Director,1 and Professor2
Richard H Osborne, NHMRC Population Health Fellow, Chair of Public Health and Director3
David Kallmes, Professor of Radiology4
1 Monash Department of Clinical Epidemiology at Cabrini Hospital, Cabrini Hospital and Monash University, Melbourne, VIC.
3 Public Health Innovation, Faculty of Health, Medicine, Nursing and Behavioural Sciences, Deakin University, Melbourne, VIC.
Voormolen M, Mali W, Lohle P, et al. Percutaneous vertebroplasty compared with optimal pain medication treatment: short-term clinical outcome of patients with subacute or chronic painful osteoporotic vertebral compression fractures. The VERTOS Study. AJNR Am J Neuroradiol 2007; 28: 555-560.
Wardlaw D, Cummings SR, Van Meirhaeghe J, et al. Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): a randomised controlled trial. Lancet 2009; 373: 1016-1024.
Kallmes DF, Comstock BA, Gray LA, et al. Baseline pain and disability in the Investigational Vertebroplasty Efficacy and Safety Trial. AJNR Am J Neuroradiol 2009; 30: 1203-1205.
Kaufmann TJ, Trout AT, Kallmes DF. The effects of cement volume on clinical outcomes of percutaneous vertebroplasty. AJNR Am J Neuroradiol 2006; 27: 1933-1937.
Rousing R, Andersen M, Jespersen S, et al. Percutaneous vertebroplasty compared with conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study. Spine 2009; 34: 1349-1354.
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