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Multidrug-resistant tuberculosis in Victoria: a 10-year review

Caroline J Lavender, Lynne K Brown and Paul D R Johnson
Med J Aust 2009; 191 (6): 315-318.
Abstract

Objective: To describe demographic and clinical characteristics of patients residing in Victoria who were diagnosed with multidrug-resistant tuberculosis (MDR-TB) during the period 1 January 1998 to 31 December 2007.

Design, setting and patients: Retrospective review of Victorian Department of Health data on laboratory-confirmed cases of MDR-TB for the period 1998–2007.

Main outcome measures: Age, sex, country of birth, time between arrival in Australia and notification of TB, residency status, site of disease, and treatment period and outcome.

Results: From 1998 to 2007, 31 patients who resided in Victoria were diagnosed with MDR-TB. The median age of patients was 27 years, most patients were born overseas, and more than half were full-time students. The median time between arrival in Australia and notification of TB was 2 years, and 24 patients were notified to the Department within 5 years of arrival. Twenty patients had pulmonary disease; in 12 of these patients, sputum was smear-positive for acid-fast bacilli. The median treatment period for patients who completed treatment was 22 months.

Conclusions: The number of patients diagnosed with MDR-TB per year increased during the period 1998–2007. If sustained, this increase will have important implications for public health policy and planning.

Multidrug-resistant tuberculosis (MDR-TB) is a major threat to global TB control. It is defined as TB with resistance to at least isoniazid and rifampicin, two of the most effective first-line anti-TB drugs, and is initially caused by the improper use of these antibiotics during the treatment of patients with drug-susceptible TB.1 However, MDR-TB is also easily transmissible, so many patients now present with no prior history of TB treatment.2

According to the World Health Organization’s fourth global report on anti-TB drug resistance, there were an estimated 489 139 new cases of MDR-TB in 2006 (4.8% of all new cases of TB), with the greatest numbers of MDR-TB cases reported from China, India and Russia.2

Australia has a low incidence of MDR-TB.1 Between 1995 and 2006, the national incidence of MDR-TB ranged from four to 22 cases per year, which corresponds to 0.5%–2.4% of bacteriologically confirmed cases of TB.3 Most patients in Australia with MDR-TB were born overseas.3

In Victoria, most cases of TB occur due to the reactivation of latent infection in people who were infected in their country of birth.4 Hence, as rates of MDR-TB increase in countries from which Australia draws most of its migrants,5,6 so does the possibility that increased rates of MDR-TB will be seen in Victoria.

The management of patients with MDR-TB is intensive, expensive and prolonged, and associated with a greater likelihood of treatment failure than drug-susceptible TB.2 Therefore, even a small increase in the number of cases of MDR-TB presents numerous challenges for clinicians and public health officials.

Here, we describe the demographic and clinical characteristics of patients residing in Victoria who were diagnosed with MDR-TB between 1998 and 2007, and discuss implications for public health policy and planning.

Methods

All patients residing in Victoria with a laboratory-confirmed diagnosis of MDR-TB that was notified to the Victorian Department of Health between 1 January 1998 and 31 December 2007 were included in the study. De-identified data were obtained from the Department of Health, and included date of notification, age at notification, sex, country of birth, year of arrival in Australia, site of disease, primary work status, residency status, epidemiological classification, TB history, treatment administration, treatment period, treatment outcome, how the case was identified, and the number of contacts screened. Contact screening usually involved a tuberculin skin test (TST) and, in some cases (depending on the TST results and the clinical history of the contact and index case), a QuantiFERON-TB test (Cellestis, Melbourne, Vic) and chest x-ray.

Univariate and bivariate analyses were performed using Stata, version 7 (StataCorp, College Station, Tex, USA). Median time between first recorded presentation to a health care worker in Australia and diagnosis of TB was calculated by using commencement of standard first-line therapy as a proxy for diagnosis and various definitions of first recorded presentation to a health care worker (eg, presentation to hospital or general practitioner, or as part of a TB undertaking [requirement for visa applicants whose chest x-ray suggests inactive TB to undergo follow-up on arrival in Australia]).

The study was approved by the Faculty of Health Sciences Human Ethics Committee at La Trobe University.

Results

From 1998 to 2007, 31 patients in Victoria were diagnosed with MDR-TB. The annual number of new cases increased during the 10-year period, and the highest number of patients diagnosed with MDR-TB in any one year was seven (in 2004, 2006 and 2007) (Box 1). Cases of MDR-TB accounted for zero to 1.1% of all TB notifications in the first half of the decade, and 0.6%–2.2% of all TB notifications in the second half.

The median age of patients with MDR-TB was 27 years (interquartile range [IQR], 23–33 years), and 16 patients were male (Box 2). Twenty-nine patients were born overseas, of whom 27 were born in countries with a high risk of TB occurrence (Box 3).7 Patients from India, Vietnam and China accounted for almost two-thirds of overseas-born patients.

For overseas-born patients, the median time between arrival in Australia and notification of TB was 2 years (IQR, 1–4 years). Of the 29 overseas-born patients, 12 were notified to the Department of Health within 2 years of arrival in Australia (four of these patients were from India), and all but six within 5 years of arrival (Box 4).

Most overseas-born patients were permanent residents (12 patients) or international students (11). Of the remaining eight patients, three were permanent residency applicants, two were Australian citizens, one was an asylum seeker, one a visitor from overseas, and one a contracted health care worker. With regard to primary work status, students (17) and full-time workers (7) accounted for more than three-quarters of patients with MDR-TB.

Twenty-six cases of MDR-TB were identified by clinical presentation, two cases were identified on the basis of the patients’ health assessment required as a condition of their TB undertaking, two cases were identified by contact investigation, and one case was identified outside Victoria. Nine patients were recorded as having a past history of TB. The median time between first recorded presentation to a health care worker in Australia and diagnosis of TB was 28 days (IQR, 8–74 days).

On the basis of epidemiological analysis and molecular typing, three cases of MDR-TB were identified as epidemiologically linked. For the 31 MDR-TB cases, a combined total of 493 contacts were screened. The number of screened contacts per case varied from zero for 11 cases to more than 50 for three cases.

Seventeen patients with MDR-TB had pulmonary disease only, 11 had extrapulmonary disease only, and three had both pulmonary and extrapulmonary disease (Box 5). In 12 patients with pulmonary disease (with or without extrapulmonary disease), sputum was smear-positive for acid-fast bacilli.

Three patients were known contacts of MDR-TB cases, and so began second-line therapy at the start of treatment. Of the remaining 28 patients, the median time between commencement of standard first-line therapy and second-line therapy was 61 days (IQR, 48–74 days). At the time of study completion, 29 patients had a treatment outcome recorded; 16 had completed treatment, seven had left Australia, three were still receiving treatment, one had left the country before commencing treatment, one did not complete treatment and was lost to follow-up, and one had died from a cause other than TB. Of those who completed treatment, about half received self-administered treatment with varying levels of external supervision, and the remainder received treatment under intense supervision (eg, by a family member or health care worker). The median treatment period for those patients who completed treatment was 22 months (IQR, 21–26 months).

Discussion

Our study revealed that there was a clear increase in the number of patients diagnosed with MDR-TB per year during the period 1998–2007. There was also a fivefold increase in the proportion of TB notifications that were accounted for by MDR-TB, which is consistent with national figures.3 New data, available since completion of our study, reveal that the increase in MDR-TB diagnoses appears to have been sustained in 2008 (six new cases of MDR-TB), although no new cases were diagnosed in the first 6 months of 2009 (TB Control Section, Victorian Department of Health, unpublished data).

If sustained, the increase in MDR-TB in Victoria will have significant implications for public health policy and planning. The management of MDR-TB involves the use of complex second- and third-line anti-TB drug regimens and, compared with drug-susceptible TB, prolonged periods of hospitalisation in negative-pressure rooms with specialist nursing care, multidisciplinary medical input and extensive use of laboratory services.8 The WHO estimates that the cost of treating a patient with MDR-TB is, on average, 100 times greater than for a patient with drug-susceptible disease.9 Investing in public health measures to prevent the transmission of MDR-TB, or to identify and treat secondary cases of both latent and active MDR-TB, can also have large financial implications.10 The finding that 12 of 20 patients with pulmonary disease in our study had smear-positive sputum, and were therefore likely to be highly infectious, highlights the importance of such measures.

TB control in Victoria and other jurisdictions of Australia is facilitated largely by migrant screening, epidemiological surveillance and bacteriological services.4 Although this approach is integral to effective TB control, our study raises questions about whether additional measures should be implemented. For example, given that the median delay between commencement of standard first-line therapy and second-line therapy was 61 days, one strategy that could be employed is the increased use of molecular tests for drug resistance. Rapid detection of drug resistance has a number of clinical and public health benefits, including earlier treatment of patients with the appropriate drug regimen, which reduces the overall period of treatment and the period of infectiousness.

As the median time between arrival in Australia and notification of TB was 2 years (indicating that some patients may have arrived with active TB), another strategy that might improve TB control is pre-departure screening for active TB, particularly in resource-limited settings. For example, the Australian Government Department of Immigration and Citizenship could develop guidelines for countries performing pre-migrant screening that outline minimum laboratory standards for TB culture testing for applicants with abnormal chest x-ray findings. Unfortunately, this strategy would still not detect most people entering Australia who have latent TB and normal chest x-ray findings when they obtain their visa (Box 6).

However, screening for latent TB will not necessarily provide a feasible solution either. Screening and treatment of migrants for latent TB as a method of TB control in low-incidence countries is a complex issue, and the evidence on clinical outcomes and cost-effectiveness of this approach is limited and contradictory.11-14 In addition, tests for latent TB, such as Mantoux tests or interferon γ release assays (eg, QuantiFERON-TB and enzyme-linked immunosorbent spot [ELISPOT] tests), do not distinguish latent TB that is fully sensitive to anti-TB drugs from MDR-TB. Isoniazid prophylaxis is also not likely to prevent reactivation of latent MDR-TB.

An intermediate approach would be to provide accessible information to those who are at high risk of TB on arrival, as most patients described in our study were diagnosed after onset of clinical symptoms. For example, as part of university orientation, international students — who accounted for more than a third of patients with MDR-TB in our study — could be provided with information on TB (eg, symptoms, risk factors) and advice on how to get help early if they are concerned about TB (eg, process of finding a doctor).

Ultimately, the elimination of TB in Australia and other low-incidence countries cannot be achieved without a coordinated global approach to TB control in high-incidence countries.15 The human impact and economic cost of MDR-TB means that continued vigilance and properly resourced community, state, national and international TB control programs remain essential.

1 Patients diagnosed with multidrug-resistant tuberculosis (MDR-TB) and all TB notifications by year, Victoria, 1998–2007

2 Patients diagnosed with multidrug-resistant tuberculosis (MDR-TB) by age and sex, Victoria, 1998–2007

3 Patients diagnosed with multidrug-resistant tuberculosis (MDR-TB) and all TB notifications by country of birth, Victoria, 1998–2007

Country of birth

No. of patients
with MDR-TB

No. of TB notifications


India*

7

485

Vietnam*

6

485

China*

4

155

Australia

2

398

Philippines*

2

156

East Timor*

2

25

Pakistan*

1

34

Eritrea*

1

27

England

1

20

South Africa*

1

15

Nepal*

1

10

Lebanon

1

9

North Korea*

1

8

Nigeria*

1

2

Other/not stated

0

1283

Total

31

3112


* Country with a high risk of TB occurrence.7

4 Overseas-born patients diagnosed with multidrug-resistant tuberculosis (MDR-TB) by time between arrival in Australia and notification of TB, Victoria, 1998–2007

5 Patients diagnosed with multidrug-resistant tuberculosis by site of disease, Victoria, 1998–2007

Site of disease

No.


Pulmonary disease only

17*

Extrapulmonary disease only

11

Lymph nodes

6

Pleura

3

Peritoneum

1

Lymph nodes + bones/joints

1

Pulmonary + extrapulmonary disease

3

Lymph nodes

1

Genitourinary tract

1

Pleura + bones/joints

1


* Sputum was positive for acid-fast bacilli in 11 patients.  Sputum was positive in one patient.

6 Chest x-rays of a patient residing in Victoria who was diagnosed with multidrug-resistant tuberculosis in 2006


A: The x-ray obtained at the time of visa application showed no evidence of active tuberculosis. B: Six months later, the x-ray performed because of a productive cough (which was first noted 4 months after visa application and 3 months after arrival in Australia) showed extensive right upper lobe consolidation and cavitation, with less extensive disease in several other pulmonary segments.

Received 
27 Jan 2009
accepted 
30 Apr 2009
Caroline J Lavender, BA, BSc(Hons), Scientist1
Lynne K Brown, DipAppSci, Manager2
Paul D R Johnson, MB BS, PhD, FRACP, Infectious Diseases Physician3
1 Mycobacterium Reference Laboratory, Victorian Infectious Diseases Reference Laboratory, Melbourne, VIC.
2 TB Control Section, Victorian Department of Health, Melbourne, VIC.
3 Austin Health, Melbourne, VIC.
Acknowledgements: 

We thank James Fielding, Victorian Department of Health, for assistance with the ethics application, and Dr Janet Fyfe and Aina Sievers, Victorian Mycobacterium Reference Laboratory, for additional details on cases. We also thank staff in the School of Public Health, in particular Dr Priscilla Robinson, and students of the Master of Public Health program, at La Trobe University for helpful discussions.

Competing Interests: 

None identified.

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