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Translational research and rational therapy: structural barriers in Australia

Richard M Fox
Med J Aust 2009; 191 (5): . || doi: 10.5694/j.1326-5377.2009.tb02776.x
Published online: 7 September 2009

“Second-generation” clinical trials are refining the use of toxic and expensive drugs, but “silo” regulatory and funding structures prevent Australia participating

The development of drugs aimed at new molecular targets exemplifies the power of translational research — “bench to bedside” translation of biomolecular science into clinical practice — to offer both significant clinical outcomes and the opportunity for commercial benefit. Classic examples are the monoclonal antibody trastuzumab for HER-2 receptor-positive breast cancer and the “designer” small-molecule inhibitor imatinib for BCR/ABL-positive chronic myeloid leukaemia.1,2 However, in Australia, there are structural constraints on funding for translational clinical research that prevent us participating fully in its clinical and financial benefits.


  • Research Directorate, St Vincent’s Hospital, Melbourne, VIC.


Correspondence: richard.fox@svhm.org.au

Competing interests:

Richard Fox is a member of the MSAC and Chair of the Cooperative Research Centre for Cancer Therapeutics; however, the views in this article are not made on behalf of these organisations.

  • 1. Drucker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008; 112: 4808-4817.
  • 2. Madarnas Y, Trudeau M, Franck JA, et al. Adjuvant/neoadjuvant trastuzumab therapy with HER-2/neu-overexpessing breast cancer: a systematic review. Cancer Treat Rev 2008; 34: 539-555.
  • 3. Bruzzi P. Non-drug industry funded research. BMJ 2008; 336: 1-2.
  • 4. Guarneri V, Frassoldati A, Bruzzi P, et al. Multicentric, randomized phase III trial of two different adjuvant chemotherapy regimes plus three versus twelve months of trastuzumab in patients with HER 2–positive breast cancer. Clinical Breast Cancer 2008; 8: 453-456.
  • 5. US National Institutes of Health. ClinicalTrials. gov. FOLFOX-4: 3 months versus 6 months and bevacizumab as adjuvant therapy for patients with stage 11/111 colon cancer (TOSCA). http://clinicaltrials.gov/ct2/show/study/NCT00646607?view=results (accessed Jul 2009).
  • 6. Bodey B, Bodey B Jr, Siegel SE, Kaiser HE. Genetically engineered monoclonal antibodies for direct anti-neoplastic treatment and cancer cell specific delivery of chemotherapeutic agents. Curr Pharm Des 2000; 6: 261-276.
  • 7. Australian Government Medicare Australia. The PBS and you. Manual for medical practitioners. PBS costs. http://www.medicareaustralia.gov.au/provider/pbs/education/pbs-and-you-manual/costs.jsp (accessed Aug 2009).
  • 8. Australian Government Department of Health and Ageing. Health technology assessment review. http://www.health.gov.au/htareview (accessed Jul 2009).

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