Challenging respiratory infections in cystic fibrosis

Abdullah A Yousef and Adam Jaffé
Med J Aust 2009; 191 (4): . || doi: 10.5694/j.1326-5377.2009.tb02767.x
Published online: 17 August 2009

To the Editor: We report a case of a 13-year-old girl with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa lung infection who developed an unusual infection that was challenging to manage. At a regular review, and with no obvious change in clinical respiratory status, the patient’s forced expiratory volume in 1 second (FEV1) was 70% of the predicted value — a drop from her usual 90%. A subsequent 3-week admission, including treatment with standard antipseudomonal antibiotics, physiotherapy and addition of nebulised dornase alfa, did not significantly improve her lung function. She was discharged home on a trial of azithromycin. One month later, she had a non-productive cough, and a bronchoalveolar lavage specimen showed no growth on culture.

  • Abdullah A Yousef1,2
  • Adam Jaffé1,2

  • 1 Department of Respiratory Medicine, Sydney Children’s Hospital, Sydney, NSW.
  • 2 School of Women’s and Children’s Health, University of New South Wales, Sydney, NSW.



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