Risks of proton-pump inhibitors: what every doctor should know

Nicholas J Talley
Med J Aust 2009; 190 (3): . || doi: 10.5694/j.1326-5377.2009.tb02305.x
Published online: 2 February 2009

No drug is completely safe and, while the risks seem small, some side effects can be serious

When I went to medical school, the mantra “know thy drugs” was pounded into me repeatedly, and it has served me well. Among the most commonly prescribed drugs in Australia are the proton-pump inhibitors (PPIs). In 2005, one million Australians were dispensed drugs in this class.1 There is no doubt that PPIs are safe relative to most other medications we prescribe, but suppressing gastric acid is not physiological.2

  • Nicholas J Talley

  • Mayo Clinic, Jacksonville, Fla, USA.


Competing interests:

I have received research support from Takeda Pharmaceutical Company Ltd and have acted as a consultant to AstraZeneca, GlaxoSmithKline and Wyeth.


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