Decrease in breast cancer incidence following a rapid fall in use of hormone replacement therapy in Australia

Karen Canfell, Emily Banks, Mark Clements, Yoon J Kang and Valerie Beral
Med J Aust 2009; 190 (3): . || doi: 10.5694/j.1326-5377.2009.tb02330.x
Published online: 2 February 2009

In reply: In saying that our work on the effect of hormone replacement therapy (HRT) on the development of breast cancer is “at best an hypothesis-generating exercise”, Giles and colleagues ignore both the preceding literature and the fact that our analysis of Australian data explicitly tested the hypothesis raised by an analysis of United States data. Both the US and Australian analyses showed falling breast cancer incidence from 2001 in women aged ≥ 50 years, but not in younger women, following large reductions in HRT use.1,2

  • Karen Canfell1,2
  • Emily Banks3
  • Mark Clements3
  • Yoon J Kang1,2
  • Valerie Beral4

  • 1 Cancer Epidemiology Research Unit, Cancer Council NSW, Sydney, NSW.
  • 2 School of Public Health, University of Sydney, Sydney, NSW.
  • 3 National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT.
  • 4 Cancer Epidemiology Unit, University of Oxford, Oxford, UK.



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