Antibiotic prophylaxis against infective endocarditis: time to rethink

Robert F W Moulds and Melanie S Jeyasingham
Med J Aust 2008; 189 (6): . || doi: 10.5694/j.1326-5377.2008.tb02044.x
Published online: 15 September 2008

A decade of research has led to more precise guidelines for a complex health problem

It has long been considered that all patients with heart conditions that predispose to infective endocarditis should receive antibiotic prophylaxis when undergoing procedures that can lead to bacteraemia with organisms known to cause endocarditis. However, the evidence for such action is surprisingly poor.1 It is based on isolated case reports of endocarditis following dental or other procedures, and on theoretical considerations, rather than the results of randomised controlled trials.

  • Robert F W Moulds1
  • Melanie S Jeyasingham2

  • 1 Fiji School of Medicine, Suva, Fiji.
  • 2 Therapeutic Guidelines Limited, Melbourne, VIC.



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