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Measuring patient-reported outcomes: moving from clinical trials into clinical practice

Jose M Valderas, Jordi Alonso and Gordon H Guyatt
Med J Aust 2008; 189 (2): 93-94.
Published online: 21 July 2008

Patient-reported outcomes (PROs) are reports coming directly from patients about how they function or feel in relation to a health condition and its therapy, without interpretation of the patient’s responses by a physician or anyone else1 (Box 1). PROs are increasingly used in clinical research, and their usefulness to inform clinicians’ and patients’ decisions about treatment alternatives is beginning to be understood.3 But results of empirical testing of using PROs in clinical practice have been inconsistent, and ascertaining the circumstances under which PROs are truly helpful beyond research settings remains a challenge.

  • Jose M Valderas1,2
  • Jordi Alonso2,3
  • Gordon H Guyatt4,5

  • 1 National Primary Care Research and Development Centre, University of Manchester, Manchester, UK.
  • 2 Health Services Research Unit, Institut Municipal d’Investigació Mèdica, Barcelona, Spain.
  • 3 CIBER en Epidemiología y Salud Pública, Barcelona, Spain.
  • 4 Department of Clinical Epidemiology and Biostatistics and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • 5 CLARITY (Clinical Advances through Research and Information Translation), McMaster University, Hamilton, Ontario, Canada.


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