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Pandemic influenza: clinical issues

Mark Boyd, Kate Clezy, Richard Lindley and Rod Pearce
Med J Aust 2006; 185 (10): 44.
  • Mark Boyd1
  • Kate Clezy2
  • Richard Lindley3
  • Rod Pearce4

  • 1 Department of Microbiology and Infectious Diseases, Flinders Medical Centre, Adelaide, SA.
  • 2 Department of Infectious Diseases, Prince of Wales Hospital, Sydney, NSW.
  • 3 Department of Geriatric Medicine, Discipline of Medicine, Westmead Hospital, University of Sydney, Sydney, NSW.
  • 4 Athelstone and Beulah Park Medical Clinic, Adelaide, SA.

Correspondence: mark.boyd@fmc.sa.gov.au

Acknowledgements: 

Professor Lindley is supported by an infrastructure grant from NSW Health.

Competing interests:

Mark Boyd has received grants to attend conferences from Merck, Sharpe and Dohme, Roche, and Gilead Sciences, and is an advisor to Roche. Rodney Pearce is an Executive Member of the Influenza Specialist Group, which receives funding from various companies, including CSL, GlaxoSmithKline, Merck, Sharpe and Dohme, and Aventis, but operates as an incorporated independent body. He has received travel expenses from the Influenza Specialist Group, and Roche paid travel expenses for him to attend the Lancet pandemic influenza meeting in Singapore, April 2006. Richard Lindley has received a donation of oseltamivir (Tamiflu) from Roche for a research project.

  • 1. Cox NJ, Subbarao K. Influenza. Lancet 1999; 354: 1277-1282.
  • 2. Monto AS, Gravenstein S, Elliott M, et al. Clinical signs and symptoms predicting influenza infection. Arch Intern Med 2000; 160: 3243-3247.
  • 3. Klimov AI, Rocha E, Hayden FG, et al. Prolonged shedding of amantadine-resistant influenzae A viruses by immunodeficient patients: detection by polymerase chain reaction-restriction analysis. J Infect Dis 1995; 172: 1352-1355.
  • 4. Englund JA, Champlin RE, Wyde PR, et al. Common emergence of amantadine- and rimantadine-resistant influenza A viruses in symptomatic immunocompromised adults. Clin Infect Dis 1998; 26: 1418-1424.
  • 5. Boivin G, Goyette N, Bernatchez H. Prolonged excretion of amantadine-resistant influenza a virus quasi species after cessation of antiviral therapy in an immunocompromised patient. Clin Infect Dis 2002; 34: E23-E25.
  • 6. Long CE, Hall CB, Cunningham CK, et al. Influenza surveillance in community-dwelling elderly compared with children. Arch Fam Med 1997; 6: 459-465.
  • 7. Frank AL, Taber LH, Wells CR, et al. Patterns of shedding of myxoviruses and paramyxoviruses in children. J Infect Dis 1981; 144: 433-441.
  • 8. Munoz FM. The impact of influenza in children. Semin Pediatr Infect Dis 2002; 13: 72-78.
  • 9. Peltola V, Ziegler T, Ruuskanen O. Influenza A and B virus infections in children. Clin Infect Dis 2003; 36: 299-305.
  • 10. Goodman RA, Orenstein WA, Munro TF, et al. Impact of influenza A in a nursing home. JAMA 1982; 247: 1451-1453.
  • 11. Babcock HM, Merz LR, Fraser VJ. Is influenza an influenza-like illness? Clinical presentation of influenza in hospitalized patients. Infect Control Hosp Epidemiol 2006; 27: 266-270.
  • 12. Melbye H, Hvidsten D, Holm A, et al. The course of C-reactive protein response in untreated upper respiratory tract infection. Br J Gen Pract 2004; 54: 653-658.
  • 13. Rabagliati BR, Serri VM, Perret PC, et al. Clinical and epidemiological characteristics of respiratory virus infections among adults hospitalized during 2004 influenza season. Rev Chilena Infectol 2006; 23: 111-117.
  • 14. Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas, and Bennett’s principles and practice of infectious diseases. 6th ed. Philadelphia: Elsevier, 2005.
  • 15. Beadling C, Slifka MK. How do viral infections predispose patients to bacterial infections? Curr Opin Infect Dis 2004; 17: 185-191.
  • 16. Togashi T, Matsuzono Y, Narita M, Morishima T. Influenza-associated acute encephalopathy in Japanese children in 1994–2002. Virus Res 2004; 103: 75-78.
  • 17. de Jong MD, Simmons CP, Thanh TT, et al. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med 2006; 12: 1203-1207.
  • 18. Sintchenko V, Gilbert GL, Coiera E, Dwyer D. Treat or test first? Decision analysis of empirical antiviral treatment of influenza virus infection versus treatment based on rapid test results. J Clin Virol 2002; 25: 15-21.
  • 19. Cooper NJ, Sutton AJ, Abrams KR, et al. Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials. BMJ 2003; 326: 1235.
  • 20. Dell KM, Schulman SL. Rhabdomyolysis and acute renal failure in a child with influenza A infection. Pediatr Nephrol 1997; 11: 363-365.
  • 21. Fujimoto S, Kobayashi M, Uemura O, et al. PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet 1998; 352: 873-875.
  • 22. Salonen O, Koshkiniemi M, Saari A, et al. Myelitis associated with influenza A virus infection. J Neurovirol 1997; 3: 83-85.
  • 23. Wells CE, James WR, Evans AD. Guillain-Barre syndrome and virus of influenza A (Asian strain); report of two fatal cases during the 1957 epidemic in Wales. AMA Arch Neurol Psychiatry 1959; 81: 699-705.
  • 24. Varma RR, Riedel DR, Komorowski RA, et al. Reye’s syndrome in nonpediatric age groups. JAMA 1979; 242: 1373-1375.
  • 25. Waldman RJ, Hall WN, McGee H, Van Amburg G. Aspirin as a risk factor in Reye’s syndrome. JAMA 1982; 247: 3089-3094.
  • 26. World Health Organization. Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO. 16 October 2006. http://www.who.int/csr/disease/avian_influenza/country/cases_table_2006_10_16/en/index.html (accessed Oct 2006).
  • 27. Beigel JH, Farrar J, Han AM, et al; Writing Committee of the World Health Organization (WHO) Consultation on Human Influenza A/H5. Avian influenza A (H5N1) infection in humans. N Engl J Med 2005; 353: 1374-1385. Erratum in N Engl J Med 2006; 354: 884.
  • 28. Simonsen L, Clarke MJ, Schonberger LB, et al. Pandemic versus epidemic influenza mortality: a pattern of changing age distribution. J Infect Dis 1998; 178: 53-60.
  • 29. Apisarnthanarak A, Kitphati R, Thongphubeth K, et al. Atypical avian influenza (H5N1). Emerg Infect Dis 2004; 10: 1321-1324.
  • 30. Chotpitayasunondh T, Ungchusak K, Hanshaoworakul W, et al. Human disease from influenza A (H5N1), Thailand, 2004. Emerg Infect Dis 2005; 11: 201-209.
  • 31. Tran TH, Nguyen TL, Nguyen TD, et al. Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med 2004; 350: 1179-1188.

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