Advances in childhood leukaemia
Authors: David S Ziegler, Luciano Dalla Pozza, Keith D Waters and Glenn M Marshall
Published online: 4 April 2005
In reply: Hocking states that electromagnetic fields cannot be ruled out as a cause of childhood leukaemia. However, several large studies have all failed to find any association between childhood exposure to electromagnetic radiation and leukaemia.1-4 The two pooled meta-analyses Hocking refers to both found no increased incidence of leukaemia with exposure to electromagnetic fields of < 0.4 microtesla.5,6 Although there was an increased risk of leukaemia with exposure to ≥ 0.4 microtesla, 99.2% of children with leukaemia had not received such a high level of exposure. 5 In addition, both studies acknowledged the potential for selection bias. As such, for the overwhelming majority of children with leukaemia, exposure to electromagnetic fields does not play any significant causative role. Although we agree its effect cannot be ruled out for the remaining < 1% of patients, it should not be given undue epidemiological weight.
References
- Linet MS, Hatch EE, Kleinerman RA, et al. Residential exposure to magnetic fields and acute lymphoblastic leukemia in children. N Engl J Med 1997; 337: 1-7. BABCJEDD
- Dockerty JD, Elwood JM, Skegg DC, Herbison GP. Electromagnetic field exposures and childhood leukaemia in New Zealand. Lancet 1999; 354: 1967-1968.
- McBride ML, Gallagher RP, Theirault G, et al. Power-frequency electric and magnetic fields and risk of childhood leukemia in Canada. Am J Epidemiol 1999; 149: 831-842.
- UK Childhood Cancer Study Investigators. Childhood cancer and residential proximity to power lines. Br J Cancer 2000; 83: 1573-1580. CBBDEJBA
- Ahlbom A, Day N, Feychting M, et al. A pooled analysis of magnetic fields and childhood leukaemia. Br J Cancer 2000; 83: 692-698. CBBHJIBC
- Greenland S, Sheppard AR, Kaune WT, et al. A pooled analysis of magnetic fields, wire codes, and childhood leukemia. Childhood Leukemia–EMF Study Group. Epidemiology 2000; 11: 624-634. CBBBCABJ
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