Two faces of research ethics

Stephen R Leeder
Med J Aust 2005; 182 (5): . || doi: 10.5694/j.1326-5377.2005.tb06661.x
Published online: 28 April 2004

Clinical trials of new medications conducted in developing countries first provoked comment in 1997, when a study of relatively low dose AZT, given late in pregnancy to HIV-positive mothers about to give birth, was compared with treatment with a placebo. By then we knew that high-dose AZT (expensive) given for a longer period during pregnancy had positive consequences for the newborn child. The idea of not treating the controls caused uproar.

  • Stephen R Leeder



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