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Malaria chemoprophylaxis: in war and peace

James S McCarthy
Med J Aust 2005; 182 (4): 148-149.

Despite recent and largely undeserved adverse publicity, mefloquine remains a useful antimalarial

James S McCarthy, FRACP, MD, Associate Professor of Tropical Medicine and Infectious Diseases
University of Queensland, Brisbane, QLD.
Article References: 
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Kitchener S. Epidemiology of malaria from East Timor among Australian Defence Force personnel. Trans R Soc Trop Med Hyg 2002; 96: 376-377.
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Charles DM, Hart J, Davis WA, et al. Notifications of imported malaria in Western Australia, 1990–2001: incidence, associated factors and chemoprophylaxis. Med J Aust 2005; 182: 164-167.
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Therapeutic guidelines: antibiotics. Melbourne: Therapeutic Guidelines Ltd, 2004.
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Meier CR, Wilcock K, Jick SS. The risk of severe depression, psychosis or panic attacks with prophylactic antimalarials. Drug Saf 2004; 27: 203-213.
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Kitchener SJ, Nasveld PE, Gregory RM, Edstein MD. Mefloquine and doxycycline malaria prophylaxis in Australian soldiers in East Timor. Med J Aust 2005; 182: 168-171.
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Overbosch D, Schilthuis H, Bienzle U, et al; Malarone International Study Team. Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study. Clin Infect Dis 2001; 33: 1015-1021.
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Steffen R, Heusser R, Machler R, et al. Malaria chemoprophylaxis among European tourists in tropical Africa: use, adverse reactions and efficacy. Bull World Health Organ 1990; 68: 313-322.
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PubMed ID: 
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Walsh DS, Eamsila C, Sasiprapha T, et al. Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malaria. J Infect Dis 2004; 190: 1456-1463.
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Davis TME, Karunajeewa HA, Illet KF. Artemisinin-based combination therapies for uncomplicated malaria. Med J Aust 2005; 182: 181-185.
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Howden BP, Vaddadi G, Manitta J, Grayson ML. Chronic falciparum malaria causing massive splenomegaly 9 years after leaving an endemic area. Med J Aust 2005; 182: 186-188.
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Alonso PL, Sacarlal J, Aponte JJ, et al. Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial. Lancet 2004; 364: 1411-1420.
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PubMed ID: 
15488216

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