Attempted repair of human spinal cord injury by transplantation of stem cells depends on complex biological interactions between the host and graft.
Extrapolating results from experimental therapy in animals to humans with spinal cord injury requires great caution.
There is great pressure on surgeons to transplant stem cells into humans with spinal cord injury. However, as the efficacy of and exact indications for this therapy are still uncertain, and morbidity (such as rejection or late tumour development) may result, only carefully designed studies based on sound experimental work which attempts to eliminate placebo effects should proceed.
Premature application of stem cell transplantation in humans with spinal cord injury should be discouraged.
- 1. Barami K, Diaz FG. Cellular transplantation and spinal cord injury. Neurosurgery 2000; 47: 691-700.
- 2. Ramon-Cueto A, Cordero MI, Santos-Benito FF, Avila J. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing cells. Neuron 2000: 25; 425-435.
- 3. Smith W. Trial offers hope to paraplegics. Herald-Sun 2002; 11 July: 2.
- 4. Bruce JN, Parsa AT. Why neurosurgeons should care about stem cells. Neurosurgery 2001; 48: 243-244.
- 5. Galvin KA, Jones DG. Adult human neural stem cells for cell-replacement therapies in the central nervous system. Med J Aust 2002; 177: 316-318. <MJA full text>
- 6. Zang D, Cheema SS. Leukemia inhibitory factor promotes recovery of locomotor function following spinal cord injury in the mouse. J Neurotrauma 2004. In press.
- 7. Gillett G. Unnecessary holes in the head. IRB 2001; 23(6): 1-6.
- 8. Goetz CG, Stebbins GT, Klawans HL, et al. United Parkinson Foundation on adrenal medullary transplants: presurgical, and 1- and 2-year follow up. Neurology 1991: 41; 1719-1722.
- 9. Greene P, Fahn P. Fetal tissue transplantation for the treatment of Parkinson’s disease. In: Tarsy D, Vitek JL, Lozano AM, editors. Surgical treatment of Parkinson’s disease and other movement disorders. Totowa, NJ: Humana Press Inc, 2003: 313-328.
- 10. Ooi ES, Chapman S. An analysis of newspaper reports of cancer breakthroughs: hope or hype. Med J Aust 2003; 179: 639-643. <MJA full text>
- 11. Raeburn CD, Zimmerman MA, Arya J, et al. Stem cells and myocardial repair. J Am Coll Surg 2002; 195: 686-693.
- 12. Kobayashi N, Okitsu T, Nakaji S, Tanaka N. Hybrid artificial liver: establishing a reversibly immortalized human hepatocyte line and developing a bioartificial liver for practical use. J Artif Organs 2003; 6: 236-244.
- 13. Kondziolka D, Wechsler L, Achim C. Neural transplantation for stroke. J Clin Neurosci 2002; 9: 225-230.
- 14. Kilpatrick TJ, Butzkueven H, Grigg A. Prospects for stem cell transplantation in multiple sclerosis. J Clin Neurosci 2002; 9: 361-367.
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