Managing the resource demands of a large sample size in clinical trials: can you succeed with fewer subjects?

Adrián V Hernández and Ewout W Steyerberg
Med J Aust 2003; 178 (7): . || doi: 10.5694/j.1326-5377.2003.tb05238.x
Published online: 7 April 2003

To the Editor: Keech and Gebski recently discussed some strategies for answering randomised clinical trial (RCT) questions with fewer subjects.1 We would like to point out another alternative for addressing this important topic — adjustment for baseline characteristics.2-4

  • Adrián V Hernández
  • Ewout W Steyerberg



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