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Determining the sample size in a clinical trial

Owen D Williamson
Med J Aust 2003; 178 (7): 358.
Published online: 7 April 2003

To the Editor: Evidence-based medicine should be supported by randomised controlled trials (RCTs) that show the efficacy of interventions in producing clinically relevant outcomes, not by those that show statistically significant, but clinically irrelevant, differences.

  • Owen D Williamson


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