Managing the resource demands of a large sample size in clinical trials: can you succeed with fewer subjects?

Anthony C Keech and Val Gebski
Med J Aust 2002; 177 (8): . || doi: 10.5694/j.1326-5377.2002.tb04888.x
Published online: 21 October 2002

In planning clinical trials, it is common to find that the calculated sample size1 (Item 7 of the CONSORT checklist; Box 1) is too large for available resources. Strategies to determine whether the trial question(s) can be answered with fewer subjects are needed. These include:

  • Anthony C Keech
  • Val Gebski

  • NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW.



remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.