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Managing the resource demands of a large sample size in clinical trials: can you succeed with fewer subjects?

Anthony C Keech and Val Gebski
Med J Aust 2002; 177 (8): 445-447.
Published online: 21 October 2002

In planning clinical trials, it is common to find that the calculated sample size1 (Item 7 of the CONSORT checklist; Box 1) is too large for available resources. Strategies to determine whether the trial question(s) can be answered with fewer subjects are needed. These include:

  • Anthony C Keech
  • Val Gebski

  • NHMRC Clinical Trials Centre, University of Sydney, Camperdown, NSW.

Correspondence: enquiry@ctc.usyd.edu.au

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