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Aspirin for the primary prevention of cardiovascular events

Graeme J Hankey and John W Eikelboom
Med J Aust 2002; 177 (7): . || doi: 10.5694/j.1326-5377.2002.tb04833.x
Published online: 7 October 2002

Benefits depend on the patient’s absolute cardiovascular and bleeding risks

The benefit of aspirin for patients with previous symptomatic atherothrombosis of the heart, brain and limb in the secondary prevention of recurrent serious vascular events is well established. However, the role of aspirin in the primary prevention of cardiovascular disease among people who have no symptoms of vascular disease is controversial.1 A recent summary of the evidence has prompted recommendations from the third US Preventive Services Task Force2,3 and the American Heart Association.4


  • Royal Perth Hospital, Perth, WA.


Correspondence: gjhankey@cyllene.uwa.edu.au

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  • 2. US Preventive Services Task Force. Aspirin for the primary prevention of cardiovascular events: recommendation and rationale. Ann Intern Med 2002; 136: 157-160.
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  • 8. Hansson L, Zanchetti AZ, Carruthers SG, et al, for the HOT Study Group. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. Lancet 1998; 351: 1755-1762.
  • 9. Low-dose aspirin and vitamin E in people at cardiovascular risk: a randomised trial in general practice. Collaborative Group of the Primary Prevention Project. Lancet 2001; 357: 89-95.
  • 10. Sudlow C. What is the role of antithrombotic treatment in asymptomatic people? In: Clinical evidence. 6th issue. London: BMJ Publishing Group, December 2001: 101-102.
  • 11. Cardiovascular risk assessment tool. Available at: http://www.med-decisions.com>. Accessed 6 September 2002.
  • 12. New Zealand cardiovascular risk calculator. National Prescribing Service Limited. Available at: <http://www.nps.org.au/docs/pdfs/cardiovascularrisk.pdf>. Accessed 6 September 2002.
  • 13. Lauer MS. Aspirin for primary prevention of coronary events. N Engl J Med 2002; 346: 1468-1474.

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