The immunobiology of early asthma

Gary P Anderson
Med J Aust 2002; 177 (6): 47.


What do we know?

What do we need to know?

Please login with your free MJA account to view this article in full

  • Gary P Anderson

  • Departments of Medicine and Pharmacology, University of Melbourne, Parkville, VIC.


  • 1. Mosmann TR, Cherwinski H, Bond MW, et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136: 2348-2357.
  • 2. Mosmann TR, Coffman RL. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 7: 145-173.
  • 3. Holt PG, Macaubas S, Prescott S, et al. Primary sensitization to inhalant allergen. Am J Respir Crit Care Med 2000; 162(3 Pt 2): S91-S94.
  • 4. Robinson DS, Hamid Q, Ying S, et al. Predominant Th2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326: 298-304.
  • 5. Morahan G, Huang D, Holt BJ, et al. Association of IL-12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 2002; 360: 455-459.
  • 6. Salvi SS, Babu KS, Holgate ST. Is asthma really due to a polarized T cell response toward a helper T cell type 2 phenotype? Am J Respir Crit Care Med 2001; 164: 1343-1346.
  • 7. Erard F, Wild MT, Garcia-Sanz JA, et al. Switch of CD8 T cells to noncytolytic CD8-CD4-cells that make Th2 cytokines and help B cells. Science 1993; 260: 1802-1805.
  • 8. Coyle AJ, Tsuyuki S, Bertrand C, et al. Mice lacking the IFN-gamma receptor have impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J Immunol 1996; 156: 2680-2685.
  • 9. Gavett SH, O'Hearn DJ, Li X, et al. Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 1995; 182: 1527-1536.
  • 10. Coyle AJ, Le Gros G, Bertrand C, et al. Interleukin-4 is required for the induction of lung Th2 mucosal immunity. Am J Respir Cell Mol Biol 1995; 13: 54-59.
  • 11. Holt PG, Macaubas C, Stumbles PA, Sly PD. The role of allergy in the development of asthma. Nature 1999; 402(6760 Suppl): B12-B17.
  • 12. Lau S, Illi S, Sommerfeld C, et al. Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group . Lancet 2000; 356: 1392-1397.
  • 13. Tsitoura DC, Kim S, Dabbagh K, et al. Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens. J Immunol 2000; 165: 3484-3491.
  • 14. Tulic MK, Wale JL, Holt PG, Sly PD. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide. Am J Respir Cell Mol Biol 2000; 22: 604-612.
  • 15. Koppelman GH, Reijmerink NE, Colin Stine O, et al Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respir Crit Care Med 2000; 163: 965-969.
  • 16. Tsitoura DC, Kim S, Dabbagh K, et al. Respiratory infection with influenza A virus interferes with the induction of tolerance to aeroallergens. J Immunol 2000; 165: 3484-3491.
  • 17. Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science 1998; 282: 2258-2261.
  • 18. Kam JC, Szefler SJ, Surs W, et al. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J Immunol 1998; 151: 3460-3466.
  • 19. Anderson GP. Therapeutic prospects for early asthma. Med J Aust 2002; 177 Suppl Sep 16: 66-69 <eMJA full text>


remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Responses are now closed for this article.