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Recent appearance of clindamycin resistance in community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in south-east Queensland

Wendy J Munckhof, Jacqueline Harper, Jacqueline Schooneveldt and Graeme R Nimmo
Med J Aust 2002; 176 (5): . || doi: 10.5694/j.1326-5377.2002.tb04391.x
Published online: 4 March 2002

To the Editor: We report the appearance of erythromycin and inducible clindamycin resistance in the south-west Pacific strain of non-multiresistant methicillin-resistant Staphylococcus aureus, which has recently appeared in eastern Australia. Infections occur predominantly in Polynesian people and are usually community-acquired. Most strains belong to Western Samoan phage patterns (WSPP1 or WSPP2) and pulsotype A when typed by pulsed-field gel electrophoresis.1,2 These strains are resistant to all β-lactams, but are usually susceptible to erythromycin, clindamycin, gentamicin, tetracycline, trimethoprim–sulfamethoxazole and ciprofloxacin. Although most of these antibiotics would not be recommended for therapy,3 clindamycin has been recommended for non-parenteral treatment of soft-tissue and bone infections, as it is efficacious in treating similar infections caused by methicillin-susceptible S. aureus.4


  • Princess Alexandra Hospital, Woolloongabba, QLD.


Correspondence: 

Acknowledgements: 

Acknowledgement: We thank the Ipswich Hospital Foundation for financial support.

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  • 2. Nimmo GR, Schooneveldt J, O'Kane G, et al. Community acquisition of gentamicin-sensitive MRSA in south-east Queensland. J Clin Microbiol 2000; 38: 3926-3931.
  • 3. Gosbell IB, Mercer JL, Neville SA, et al. Non-multiresistant and multiresistant methicillin-resistant Staphylococcus aureus in community-acquired infections. Med J Aust 2001; 174: 627-620.
  • 4. Therapeutic Guidelines Limited. Therapeutic guidelines: antibiotic. Version 11, 2000. Melbourne: Therapeutic Guidelines Limited, 2000.
  • 5. Garrod LP, Lambert HP, O'Grady F. Antibiotic and chemotherapy. 4th ed. Edinburgh, Churchill Livingstone, 1973.
  • 6. Gosbell IB, Mercer JL, Neville SA, et al. Community-acquired, non-multiresistant oxacillin-resistant Staphylococcus aureus (NORSA) in south western Sydney. Pathology 2001; 33: 206-210.
  • 7. Panagea S, Perry JD, Gould FK. Should clindamycin be used as treatment of patients with infections caused by erythromycin-resistant staphylococci? J Antimicrob Chemother 1999; 44: 581-582.

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