Thrombophilia screening and adverse pregnancy outcomes associated with uteroplacental insufficiency

David Morgans
Med J Aust 2002; 176 (12): . || doi: 10.5694/j.1326-5377.2002.tb04597.x
Published online: 17 June 2002

To the Editor: The recent article by the Obstetric Medicine Group of Australasia alluded to the increasing relevance and importance of thrombophilia screening following adverse pregnancy outcomes, namely recurrent miscarriage, stillbirth, retarded intrauterine growth and pre-eclampsia.1 Formerly, these outcomes were generally attributed to "placental insufficiency", where a cause was not readily identified.


  • 1. Hague WM, North RA, Gallus AS, et al. Anticoagulation in pregnancy and the puerperium. Med J Aust 2001; 175: 258-263.
  • 2. Brenner B. Inherited thrombophilia and pregnancy loss. Thromb Haemost 1999; 82: 634-640.
  • 3. Brenner B, Hoffman R, Blumenfeld Z, et al. Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by Enoxaparin. Thromb Haemost 2000; 83: 693-697.
  • 4. Preston FE, Rosendaal FR, Walker ID, et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 913-916.
  • 5. Rai R, Regun L, Hadley E, et al. Second trimester pregnancy loss is associated with activated protein C resistance. Br J Haematol 1996; 92: 489-490.


remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.