Hyponatraemia and hypokalaemia caused by indapamide

Laurence G Howes, John McEwen and John E Marley
Med J Aust 2002; 176 (12): . || doi: 10.5694/j.1326-5377.2002.tb04578.x
Published online: 17 June 2002

In reply: Howes writes that previous studies have not shown significant hyponatraemia with indapamide. Our article highlighted that hyponatraemia was reported in a much larger proportion of all types of adverse drug reactions to indapamide than to chlorothiazide in Australia. As we clearly acknowledged, "Voluntary reporting systems do not provide a basis for calculating incidence or robust risk estimates".

  • 1 Department of Clinical Pharmacology, St George Hospital, Kogarah, NSW.
  • 2 Adverse Drug Reactions Unit, Therapeutic Goods Administration, Woden, ACT.
  • 3 The University of Newcastle, Newcastle, NSW.



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