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Adulthood – prevention

Paul J Nestel
Med J Aust 2002; 176 (11): . || doi: 10.5694/j.1326-5377.2002.tb04572.x
Published online: 3 June 2002

How much and which kind of fat? This has remained a surprisingly divisive issue. Surprising because the Australian population has gradually reduced fat consumption from over 40% of energy in the middle of the last century to a little over 30% by the end. This has coincided with a substantial reduction in heart attack prevalence. However, the evidence that the quantity of fat is linked to coronary heart disease (CHD) is weak — it is the quality of the dietary fatty acids that matters.1 After all, CHD prevalence remains low in southern Europe, despite high intakes of lipid, mostly as vegetable oils. Prospective cohort studies and intervention trials, both primary and secondary, point that way. The positive link between dietary saturated fat and CHD is strong, as is the evidence that substituting polyunsaturated fatty acids (PUFAs, linoleic acid) for saturates lowers CHD risk. Whereas PUFAs are part of the eating pattern associated with least CHD in prospective trials, the opposite holds for saturates.2,3


  • Cardiovascular Nutrition Laboratory, Baker Medical Research Institute, Prahran, VIC, Australia.


Correspondence: 

  • 1. National Heart Foundation of Australia. A review of the relationship between dietary fat and cardiovascular disease. Aust J Nutr Diet 1999; 56 (Suppl): S2-S22.
  • 2. Stampfer MJ, Hu FB, Manson JE, et al. Primary prevention in coronary heart disease in women through diet and lifestyle. New Engl J Med 2000; 343: 16-22.
  • 3. Hu FB, Rimm EB, Stampfer MJ, et al. Prospective study of major dietary patterns and risk of heart disease in men. Am J Clin Nutr 2000; 72: 912-921.
  • 4. Nestel PJ. Saturated and trans fatty acids and coronary heart disease. Eur Heart J 1999; 1 (suppl S): S19-S23.
  • 5. Zock PL, Katan MB. Linoleic acid intake and cancer risk: a review and meta-analysis. Am J Clin Nutr 1998; 68: 142-153.
  • 6. Parodi PW. Conjugated linoleic acid. Food Australia 2002; 54: 96-99.
  • 7. Marckmann P, Gronbaek M. Fish consumption and coronary heart disease mortality. A systematic review of prospective cohort studies. Eur J Clin Nutr 1999; 53: 585-590.
  • 8. GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 1999; 447: 447-455.
  • 9. Albert CM, Hennekens CH, O'Donnell CJ, et al. Fish consumption and risk of sudden cardiac death. JAMA 1998; 279: 23-28.
  • 10. Nestel P. Effects of fish oils and fish on cardiovascular disease. Curr Atheroscler Rep 2001; 3: 68-73.
  • 11. De Lorgeril M, Salen P, Martin JL, et al. Mediterranean diet, traditional risk factors and the rate of cardiovascular complications after myocardial infarction. Circulation 1999; 99: 779-785.

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