Clinical pharmacology is the clinical application of the action of drugs on the body, and involves understanding how the body handles and modifies drugs, and their side effects and interactions. Significant advances have occurred in the development of new drugs, and the genetics of drug actions, metabolism and transporters.
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Gillian M Shenfield, David G Le Couteur and Laurent P Rivory
Med J Aust 2002; 176 (1): 9.
Gillian M Shenfield, DM, FRACP, Clinical Professor in Clinical Pharmacology1
David G Le Couteur, PhD, FRACP, Professor of Geriatrics2
Laurent P Rivory, PhD, Senior Hospital Scientist3
Destenaves B, Thomas F. New advances in pharmacogenetics. Curr Opin Chem Biol 2000; 4: 440-444.
Wolf CR, Smith G, Smith RL. Pharmacogenetics. BMJ 2000; 320: 987-990.
Rodrigues AD. Integrated cytochrome P450 reaction phenotyping. Attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes. Biochem Pharmacol 1999; 57: 465-480.
Tanaka E. Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes. J Clin Pharm Ther 1998; 23: 403-416.
Yu DK. The contribution of P-glycoprotein to pharmacokinetic drug-drug interactions. J Clin Pharmacol 1999; 39: 1203-1211.
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