Anatomical pathology

Duncan P MacGregor
Med J Aust 2002; 176 (1): . || doi: 10.5694/j.1326-5377.2002.tb04240.x
Published online: 7 January 2002

An Australian study, published in 1998, described histological features of breast cancers occurring in young women with germline mutations in two specific genes.1 In 2000, a multicentre US group conducting molecular analysis of a series of diffuse large B-cell lymphomas reported that, within this group of morphologically indistinguishable tumours, two distinct types of lymphoma could be identified by gene-expression profiles, and that these two types had significantly different prognoses.2

  • Department of Anatomical Pathology, Austin and Repatriation Medical Centre, Heidelberg, VIC.

  • 1. Armes JE, Egan AJ, Southey MC, et al. The histological phenotypes of breast carcinoma occurring before age 40 years in women with and without BRCA1 or BRCA2 germline mutations. Cancer 1998; 83: 2335-2345.
  • 2. Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403(6769): 503-511.
  • 3. Horvath L, Henshall S. The application of tissue microarrays to cancer research. Pathology 2001; 33(2): 125-129.


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