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The gluten‐free diet: an historical perspective and its use by people without coeliac disease

Amanda Cartee and Joseph A Murray
Med J Aust 2020; 212 (3): . || doi: 10.5694/mja2.50488
Published online: 17 February 2020

The long term benefits and risks of gluten avoidance for people without coeliac disease are unknown

Interest in food and its connection with disease dates back to ancient medicine.1 Despite scientific and technological advances, diet modifications continue to have a role in medicine, and certain foods are directly involved in some conditions or symptoms.2,3


  • Mayo Clinic, Rochester, MN, United States of America


Correspondence: Murray.joseph@mayo.edu

Competing interests:

Joseph A. Murray receives grant support from Nexpep/ImmusanT, the National Institutes of Health, Immunogenix, Takeda Pharmaceutical, Allakos, the Oberkotter Foundation, and Cour; he is a consultant to Bionix, Lilly Research Laboratory, Johnson & Johnson, Dr. Schär USA, UCB Biopharma, Innovate Biopharmaceuticals, Glenmark Pharmaceuticals, Celimmune, Amgen Intrexon Corporation, Kanyos, Boehringer Ingelheim, and Chugai Pharmaceuticals. Joseph A. Murray holds patents licensed to Evelo Biosciences, and receives royalties from Torax Medical.

  • 1. Wilkins J. Good food and bad: nutritional and pleasurable eating in ancient Greece. J Ethopharmacol 2015; 176: 7–10.
  • 2. Sampson HA. Food allergy: past, present and future. Allergol Int 2016; 65: 363–369.
  • 3. Yngve A. A historical perspective of the understanding of the link between diet and coronary heart disease. Am J Lifestyle Med 2009; 3 (1 Suppl): 35S–38S.
  • 4. Losowsky MS. A history of coeliac disease. Dig Dis 2008; 26: 112–120.
  • 5. Niland B, Cash BD. Health benefits and adverse effects of a gluten‐free diet in non‐celiac disease patients. Gastroenterol Hepatol (NY) 2018; 14: 82–91.
  • 6. Cooper BT. Gluten‐sensitive diarrhea without evidence of celiac disease. Gastroenterology 1980; 79: 801–806.
  • 7. Choung RS, Unalp‐Arida A, Ruhl CE, et al. Less hidden celiac disease but with increased gluten avoidance without a diagnosis in the United States: findings from the National Health and Nutrition Examination Surveys from 2009 to 2014. Mayo Clin Proc 2017; 92: 30–38.
  • 8. Skodje GI, Sarna VK, Minelle IH, et al. Fructan, rather than gluten, induces symptoms in patients with self‐reported non‐celiac gluten sensitivity. Gastroenterology 2018; 154: 529–539.
  • 9. Cartee AK, King KS, Want S, et al. An acute rise in serum IL‐2 levels but not symptoms differentiates celiac disease subjects from non‐celiac gluten sensitivity and healthy subjects in a single dose randomized double blind placebo controlled gluten challenge [abstract]. Gastroenterology 2019; 156 (6 Suppl): S177–S178.
  • 10. Goel G, Tye‐Din JA, Qiao SW, et al. Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease. Sci Adv 2019; 5: eaaw7756.
  • 11. Potter MDE, Jones MP, Walker MM, et al. Incidence and prevalence of self‐reported non‐coeliac wheat sensitivity and gluten avoidance in Australia. Med J Aust 2020; 212: 126–131.
  • 12. Shepherd SJ, Gibson PR. Nutritional inadequacies of the gluten‐free diet in both recently‐diagnosed and long‐term patients with coeliac disease. J Hum Nutr Diet 2013; 26: 349–358.
  • 13. Raehsler SL, Choung RS, Marietta EV, Murray JA. Accumulation of heavy metals in people on a gluten free diet. Clin Gastroenterol Hepatol 2018; 16: 244–251.

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