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Cluster randomised trials

Michael J Campbell
Med J Aust 2019; 210 (4): . || doi: 10.5694/mja2.13001
Published online: 4 March 2019

Cluster randomised trials randomise groups of individuals rather than individuals themselves to interventions. The groups might be communities, schools, workplaces, hospitals, or patients treated by a particular doctor. There are a number of reasons for the use of cluster trials as opposed to individually randomised trials. They may be the only available choice, as when a city is randomised to a mass intervention. Another reason is that the investigators may wish to reduce the risk of contamination (Box 1), or it may be more effective, more convenient or cheaper to deliver an intervention to a group rather than to an individual. For example, patients in the same education program will interact with each other and may learn better together than on their own, making a course more effective and economical than one‐on‐one tuition.

  • Michael J Campbell

  • University of Sheffield, Sheffield, UK

Series Editors

John R Attia

Michael P Jones


Competing interests:

No relevant disclosures.

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