Volume 201 - Issue 2
Black bones: minocycline-induced bone pigmentation
Authors: Vishnusai Chauhan and Catherine McDougall
Med J Aust 2014; 201 (2): 114. || doi: 10.5694/mja14.00446
Published online: 21 July 2014
Published online: 21 July 2014
A known cause with no cause for alarm
An 82-year-old man with bilateral knee osteoarthritis underwent consecutive total knee arthroplasty 5 months apart. During both procedures, he was noted to have black subchondral bone with otherwise normal architecture and normal-coloured cancellous bone. At the time of surgery, bone specimens sent for pathology testing were histologically normal. The patient had been treated with minocycline for rosacea for 7 months before the first procedure. Minocycline is an uncommon cause of skeletal pigmentation and is not known to affect bone quality.1 Discolouration may also be owing to ochronosis, metal deposits, sequestrum and metastatic disease.2
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