To the Editor: Gruen and colleagues1 have not accurately represented the current safety data on the risk of vascular occlusive events (VOE) with tranexamic acid (TxA), including deep vein thrombosis (DVT) and pulmonary embolism (PE).
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- 1. Gruen RL, Jacobs IG, Reade MC; PATCH-Trauma study investigators. Trauma and tranexamic acid. Med J Aust 2013; 199: 310-311. <MJA full text>
- 2. Ker K, Edwards P, Perel P, et al. Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ 2012; 344: e3054.
- 3. Shakur H, Roberts I, Bautista R, et al; CRASH-2 Trial Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo controlled trial. Lancet 2010; 376: 23-32.
- 4. Morrison J, Dubose J, Rasmussen T, Midwinter M. Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. Arch Surg 2012; 147: 113-119.
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