Is there really misuse and abuse of dabigatran?

John W Eikelboom and Graeme J Hankey
Med J Aust 2013; 198 (7): 358-359. || doi: 10.5694/mja12.11642
Published online: 15 April 2013

A brief commentary on the RE-LY study

Patient selection in the RE-LY trial

The RE-LY (Randomized Evaluation of Long-Term Anticoagulant Therapy) trial of dabigatran versus warfarin included patients with all degrees of risk of stroke and systemic embolism.9 If the trial had excluded participants with a low risk, ie, a CHADS2 score of 1 (congestive heart failure, hypertension, age ≥ 75 years, diabetes, 1 point each; prior stroke or transient ischaemic attack, 2 points), clinicians would not now know that these patients derive benefit from dabigatran compared with warfarin.

Provenance: Commissioned; externally peer reviewed.

  • John W Eikelboom1
  • Graeme J Hankey2

  • 1 Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
  • 2 School of Medicine and Pharmacology, University of Western Australia, Perth, WA.


Competing interests:

John Eikelboom was a member of the RE-LY Steering Committee and has received honoraria and grant support from the manufacturers of new oral anticoagulants including Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Janssen and Pfizer. Graeme Hankey has received honoraria for serving on the executive steering committees of the ROCKET-AF trial (Johnson and Johnson), the AMADEUS and BOREALIS trials (Sanofi), and the stroke outcome adjudication committees of the RE-LY trial and AVERROES trial, and has received honoraria from Bayer, Boehringer Ingelheim, Bristol-Myers Squibb and Pfizer for speaking at sponsored scientific symposia and consulting on advisory boards.

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