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Pandemic (H1N1) 2009

Life-threatening respiratory failure from H1N1 influenza 09  (human swine influenza)

Melissa A Kaufman, Graeme J Duke, Forbes McGain, Craig French, Craig Aboltins, Gary Lane and Geoff A Gutteridge
Med J Aust 2009; 191 (3): 154-156.

We present the first six cases of H1N1 influenza 09 (confirmed by a polymerase chain reaction test from nasopharyngeal swabs) in patients requiring admission to intensive care in Australia (in three hospitals in the north-western suburbs of Melbourne). These cases highlight the small but significant risk of life-threatening respiratory failure associated with H1N1 influenza 09 infection.

Melissa A Kaufman, MB BS, Intensive Care Registrar1
Graeme J Duke, MD, FJFICM, FANZCA, Critical Care Director1
Forbes McGain, FJFICM, FANZCA, Intensive Care Specialist2
Craig French, FJFICM, FANZCA, Intensive Care Director2
Craig Aboltins, MB BS, FRACP, Infectious Diseases Specialist1
Gary Lane, FRACP, MMed(ClinEpi), MQIHC, Infectious Diseases Specialist2
Geoff A Gutteridge, FJFICM, FANZCA, Intensive Care Director3
1 Northern Hospital, Melbourne, VIC.
2 Western Hospital, Melbourne, VIC.
3 Austin Hospital, Melbourne, VIC.
Article References: 
Reference Text: 
World Health Organization. Epidemic and Pandemic Alert and Response (EPR). Influenza A(H1N1) — update 53. Laboratory-confirmed cases of new influenza A(H1N1) as officially reported to WHO by States Parties to the International Health Regulations (2005). http://www.who.int/csr/don/2009_06_24/en/index.html (accessed Jun 2009).
Reference Order: 
1
PubMed ID: 
Reference Text: 
Thoracic Society of Australia and New Zealand. TSANZ swine flu update June 29th, 2009. http://www.thoracic.org.au/H1N1SwineFlu.pdf (accessed Jul 2009).
Reference Order: 
2
PubMed ID: 
Reference Text: 
Centers for Disease Control and Prevention. Hospitalized patients with novel influenza A(H1N1) virus infection — California, April–May 2009. MMWR Morb Mortal Wkly Rep 2009; 58: 470-472.
Reference Order: 
3
PubMed ID: 
19444151
Reference Text: 
Chowell G, Bertozzi SM, Colchero MA, et al. Severe respiratory disease concurrent with the circulation of H1N1 influenza. N Engl J Med 2009; 29 Jun [Epub ahead of print].
Reference Order: 
4
PubMed ID: 
Reference Text: 
Cheng AC, Dwyer DE, Kotsimbos ATC, et al. ASID/TSANZ guidelines: treatment and prevention of H1N1 influenza 09 (human swine influenza) with antiviral agents. Med J Aust 2009; 18 Jun, updated 7 Jul [Epub ahead of print].
Reference Order: 
5
PubMed ID: 
Reference Text: 
Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009; 360: 2667-2668.
Reference Order: 
6
PubMed ID: 
19423870
Reference Text: 
Centers for Disease Control and Prevention. Interim CDC guidance for infection control for care of patients with confirmed or suspected novel influenza A (H1N1) virus infection in a healthcare setting. 13 May 2009. http://www.cdc.gov/h1n1flu/guidelines_infection_control.htm (accessed Jun 2009).
Reference Order: 
7
PubMed ID: 
Reference Text: 
Centers for Disease Control and Prevention. Novel influenza A (H1N1) virus infections in three pregnant women — United States, April–May 2009. MMWR Morb Mortal Wkly Rep 2009; 58: 497-500.
Reference Order: 
8
PubMed ID: 
19444154
Reference Text: 
World Health Organization. Influenza A(H1N1) virus resistance to oseltamivir — 2008/2009 influenza season, northern hemisphere. 18 Mar 2009. http://www.who.int/csr/disease/influenza/H1N1webupdate 20090318%20ed_ns.pdf (accessed Jun 2009).
Reference Order: 
9
PubMed ID: 
Reference Text: 
Centers for Disease Control and Prevention. Update: drug susceptibility of swine-origin influenza A (H1N1) viruses, April 2009. MMWR Morb Mortal Wkly Rep 2009; 58: 433-435.
Reference Order: 
10
PubMed ID: 
19407738
Reference Text: 
Perez Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, et al. Pneumonia and respiratory failure from swine-origin Influenza A (H1N1) in Mexico. N Engl J Med 2009; 29 Jun [Epub ahead of print].
Reference Order: 
11
PubMed ID: 
Reference Text: 
Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308.
Reference Order: 
12
PubMed ID: 
10793162
Reference Text: 
Delclaux C, L’Her E, Alberti C, et al. Treatment of acute hypoxemic nonhypercapnic respiratory insufficiency with continuous positive airway pressure delivered by a face mask. A randomized controlled trial. JAMA 2000; 284: 2352-2360.
Reference Order: 
13
PubMed ID: 
11066186
Reference Text: 
British Thoracic Society Standards of Care Committee. Non-invasive ventilation in acute respiratory failure. Thorax 2002; 57: 192-211.
Reference Order: 
14
PubMed ID: 
11867822

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