Thirty-year follow-up at pneumonectomy of a 58-year-old survivor of disseminated osteosarcoma

George A Jelinek and Ruth H Gawler
Med J Aust 2008; 189 (11): . || doi: 10.5694/j.1326-5377.2008.tb02234.x
Published online: 1 December 2008

A 1978 case report in the Journal described a 25-year-old man with disseminated osteogenic sarcoma whose metastases regressed after treatment with diet and intensive meditation. Thirty years later, there has been no recurrence of his cancer, and a recent pneumonectomy for chronic bronchiectasis revealed mature cancellous bone in the resected lung. The man is otherwise well. (MJA 2008; 189: 663-665)

A man who is now 58 years old was diagnosed in 1974, at the age of 24, with histologically confirmed high-grade osteogenic sarcoma of the right femur (Figure, A). His right leg was amputated in January 1975. Histopathologically, the tumour was described (in a 1994 review of the case) as follows: “The tissue is replaced by a cellular malignant spindle cell tumour forming osteoid and bone and having a disorganised pattern of proliferation . . . confirming the diagnosis of a high grade endosteal osteosarcoma (osteogenic sarcoma).”

  • 1 Department of Medicine, University of Melbourne, St Vincent’s Hospital, Melbourne, VIC.
  • 2 Department of Emergency Medicine, St Vincent’s Hospital, Melbourne, VIC.
  • 3 The Gawler Foundation, Yarra Junction, VIC.



We are grateful to Professor Peter Clarke, who performed the pneumonectomy, and Mr John Doyle, who undertook the amputation, for their assistance with the provision of past records and review of the manuscript, and to Dr Sandra Neate for her critical review and helpful suggestions.

Competing interests:

Professor Jelinek is a friend and colleague of the patient, and Dr Gawler is related to the patient.

  • 1. Meares A. Regression of osteogenic sarcoma metastases associated with intensive meditation. Med J Aust 1978; 2: 433.
  • 2. Picci P. Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis 2007; 2: 6.
  • 3. Jaffe N, Carrasco H, Raymond K, et al. Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery? Cancer 2002; 95: 2202-2210.
  • 4. Wittig JC, Bickels J, Priebat D, et al. Osteosarcoma: a multidisciplinary approach to diagnosis and treatment. Am Fam Physician 2002; 65: 1123-1132.
  • 5. Tan JZ, Schlicht SM, Powell GJ, et al. Multidisciplinary approach to diagnosis and management of osteosarcoma — a review of the St Vincent’s Hospital experience. Int Semin Surg Oncol 2006; 3: 38.
  • 6. Strauss SJ, McTiernan A, Whelan JS. Late relapse of osteosarcoma: implications for follow-up and screening. Pediatr Blood Cancer 2004; 43: 692-697.
  • 7. Kim MS, Sim YS, Lee SY, Jeon DG. Secondary thyroid papillary carcinoma in osteosarcoma patients: report of two cases. J Korean Med Sci 2008; 23: 149-152.
  • 8. Longhi A, Ferrari S, Bacci G, Specchia S. Long-term follow-up of patients with doxorubicin-induced cardiac toxicity after chemotherapy for osteosarcoma. Anticancer Drugs 2007; 18: 737-744.
  • 9. Bacci G, Palmerini E, Staals EL, et al. Spontaneous regression of lung metastasis from osteosarcoma: a case report. J Pediatr Hematol Oncol 2008; 30: 90-92.
  • 10. Gerson M. A cancer therapy: results of fifty cases. New York: Station Hill Press, 1995.
  • 11. Ornish D, Magbanua MJ, Weidner G, et al. Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention. Proc Natl Acad Sci U S A 2008; 105: 8369-8374.


remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.