Clinical staging: a heuristic model for psychiatry and youth mental health

Patrick D McGorry, Rosemary Purcell, Ian B Hickie, Alison R Yung, Christos Pantelis and Henry J Jackson
Med J Aust 2007; 187 (7 Suppl): S40.


  • Patrick D McGorry1,2
  • Rosemary Purcell2,3,4
  • Ian B Hickie5
  • Alison R Yung6,2
  • Christos Pantelis7
  • Henry J Jackson2,8,8

  • 1 University of Melbourne, Melbourne, VIC.
  • 2 ORYGEN Research Centre, University of Melbourne, Melbourne, VIC.
  • 3 Department of Psychiatry, University of Melbourne, Melbourne, VIC.
  • 4 Centre of Excellence, headspace: The National Youth Mental Health Foundation, Melbourne, VIC.
  • 5 Brain and Mind Research Institute, University of Sydney, Sydney, NSW.
  • 6 PACE Clinic, ORYGEN Youth Health, Melbourne, VIC.
  • 7 Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, VIC.
  • 8 Department of Psychology, University of Melbourne, Melbourne, VIC.


Competing interests:

Christos Pantelis receives support to attend meetings as well as speaker fees. He is also on various advisory boards. However, none of these relate to the material in this article.

  • 1. Osler W. The principles and practice of medicine. 1st ed. New York: D Appleton & Co, 1892.
  • 2. Kendell R, Jablensky A. Distinguishing between the validity and utility of psychiatric diagnoses. Am J Psychiatry 2003; 160: 4-12.
  • 3. Kendler KS. Reflections of the relationship between psychiatric genetics and psychiatric nosology. Am J Psychiatry 2006; 163: 1138-1146.
  • 4. Fava GA, Kellner R. Staging: a neglected dimension in psychiatric classification. Acta Psychiatr Scand 1993; 87: 225-230.
  • 5. McGorry PD, Hickie IB, Yung AR, et al. Clinical staging of psychiatric disorders: a heuristic framework for choosing earlier, safer and more effective interventions. Aust N Z J Psychiatry 2006; 40: 616-622.
  • 6. Mader JT, Shirtliff M, Calhoun JH. Staging and staging application in osteomyelitis. Clin Infect Dis 1997; 25: 1303-1309.
  • 7. Müller-Quernheim J. Sarcoidosis: immunopathogenetic concepts and their clinical application. Eur Respir J 1998; 12: 716-738.
  • 8. Hasselbach HC. Idiopathic myelofibrosis — an update with particular reference to clinical aspects and prognosis. Int J Clin Lab Res 1993; 23: 124-138.
  • 9. Malla AK, Norman RM, Joober R. First-episode psychosis, early intervention and outcome: what have we learned? Can J Psychiatry 2005; 50: 881-891.
  • 10. Harrison G, Hopper K, Craig T, et al. Recovery from psychotic illness: a 15-and 25-year international follow-up study. Br J Psychiatry 2001; 178: 506-517.
  • 11. van Os J, McGuffin P. Can the social environment cause schizophrenia? Br J Psychiatry 2003; 182: 291-292.
  • 12. Poulton R, Caspi A, Moffitt TE, et al. Children’s self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Arch Gen Psychiatry 2000; 57: 1053-1058.
  • 13. Tienari P, Wynne C, Sorri A, et al. Genotype–environment interaction in schizophrenia-spectrum disorder. Br J Psychiatry 2004; 184: 216-222.
  • 14. McGorry PD, Copolov DL, Singh BS. Current concepts in functional psychosis. The case for a loosening of associations. Schizophr Res 1990; 3: 221-234.
  • 15. Craddock N, Owen MJ. The beginning of the end for the Kraepelinian dichotomy. Br J Psychiatry 2005; 186: 364-366.
  • 16. Lieberman JA, First MB. Renaming schizophrenia. BMJ 2007; 334: 108.
  • 17. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160: 636-645.


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