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Men’s reactions to disclosed and undisclosed opportunistic PSA screening for prostate cancer

Melina Gattellari and Jeanette E Ward
Med J Aust 2005; 182 (8): 386-389.
Published online: 18 April 2005

Abstract

Objective: To assess the degree to which men considered it appropriate for general practitioners to order prostate-specific antigen (PSA) testing if the testing was either “disclosed” or “undisclosed” to the patient.

Design: Telephone-administered survey conducted in June to October 2000.

Participants: 514 men aged 50–70 years, identified by random selection of households from the Sydney Electronic White Pages phone directory.

Methods: We developed two hypothetical scenarios. Each scenario described a GP ordering a PSA test for a male patient at the same time as other pathology tests were ordered. In Scenario 1, the GP’s intention to order a PSA test was disclosed to the patient (“disclosed”). In Scenario 2, the GP did not tell the patient a PSA test was being ordered (“undisclosed”). For each scenario, men reported the degree to which they perceived screening to be “appropriate”. We also recorded demographic characteristics, health status and health locus of control, and administered a 14-question knowledge test about prostate cancer and PSA screening.

Results: Over 90% of men stated that “disclosed” PSA screening was either “appropriate” or “very appropriate”. Significantly fewer (44.9%) rated “undisclosed” screening as appropriate/very appropriate (P < 0.001). While the skewed distribution of responses to Scenario 1 precluded multivariate analysis to determine predictors, men rejecting “undisclosed” PSA screening (Scenario 2) were more likely to be younger (adjusted odds ratio [AOR], 0.97; 95% CI, 0.94–1.00; P = 0.03); to have better knowledge of the issues (AOR, 1.01; 95% CI, 1.00–1.03; P = 0.02); and to be single (AOR, 0.62; 95% CI, 0.41–0.94; P = 0.02).

Conclusions: Many men consider that inclusion of PSA screening within a battery of pathology tests without disclosure to the patient is unacceptable. Educating men about the pros and cons of screening may alter their support of opportunistic screening and thus enhance community expectations of “informed participation”.

Screening for prostate cancer by prostate-specific antigen (PSA) testing is contentious.1-5 In a recent systematic review, the US Preventive Services Taskforce concluded:

We are unable to determine the net benefit of screening because we cannot establish the presence and, if present, the magnitude of benefit from screening. We can establish the presence of potential harms. Whether screening would result in benefit, and whether that benefit would outweigh the attendant harms, is unknown.5

All protagonists in the public controversy agree that men should make an “informed decision” about whether or not to undergo PSA screening,1,4 and, hence, need to be fully apprised of the arguments for and against it.6-9

It appears that men participate in PSA screening without their full knowledge. Diefenbach et al10 surveyed 369 Californian men for whom there was corroborated evidence of their having had a PSA test in the previous 2 weeks. Only 26.6% recalled being informed at the time of testing that a PSA test was being ordered. Federman et al11 reported that 31% of a sample of 173 men who had had PSA screening 3 months earlier were unaware that a PSA test had been ordered. An Australian study revealed that 38% of men who had had a screening test for prostate cancer during the previous 5 years could not recall their doctor discussing the pros and cons of screening. A further 39% recalled 5 or fewer minutes dedicated to such a discussion.12 While these studies may be affected by recall bias, they suggest that the pros and cons of PSA screening are not adequately discussed with men.

As general practitioners order PSA tests “opportunistically” when requesting other pathology tests,13 it has been argued that patient autonomy is undermined by such an approach, while GPs are increasing the medicolegal risk to themselves.1-4 As men’s views on PSA screening are relatively unknown, we designed a community survey to explore the appropriateness of screening from their perspective.

Methods
Participants

This study was part of a larger study in which we recruited participants by random selection of households from the Electronic White Pages phone directory. As reported elsewhere in detail,14,15 we recruited a representative sample of men aged 50–70 years living in Sydney. Men who had a history of prostate cancer or who were not fluent in English were excluded.

Interviews

One of 10 trained interviewers from a non-profit market research company (the Hunter Valley Research Foundation) established contact with each household to identify eligible participants and obtain their consent. Once consent was obtained, the interviewer proceeded to administer our computer-assisted telephone interview (CATI). Interviewers first elicited health information (current smoking, previous heart attack/stroke, self-reported health status). Answers to specific questions were used to derive a score (between 1 and 6) on a health locus of control scale16 (a higher score indicating a greater tendency to attribute health status to chance or “luck”) and a rating on a control preferences scale (a measure of whether an individual prefers a “passive”, “collaborative” or “active” role in medical decision making). Each participant was then presented with two scenarios relating to PSA screening (see below). Participants were also asked 14 questions (in a combination of “true/false” and multiple choice formats) that assessed their knowledge about aspects of prostate cancer (eg, efficacy of PSA screening, risk factors for prostate cancer, treatment side effects). Demographic details (eg, marital status, country of birth, education level, occupation) were elicited at the end of the interview. Interviews were completed between June and October 2000.

A random sample of about 10% of each interviewer’s telephone calls (53 calls in total) was monitored throughout the interview process to ensure that interviewers adhered to the wording on the CATI screen.

Scenarios

After being given a description of the PSA test to ensure they understood its purpose and how it was performed, participants were presented with two hypothetical scenarios relating to opportunistic PSA screening. The first scenario described a GP ordering a PSA test along with other blood pathology tests after disclosing the intention to include the PSA test:

Scenario 1 (“disclosed” opportunistic PSA screening):

Mr A is a man in his early 60s. He sees a GP to check his blood pressure before going on a holiday. He is fit and well. He has no symptoms to suggest he has prostate cancer. While he is there, the doctor orders some blood tests. Mr A does not ask the doctor about PSA tests. However, the doctor suggests to Mr A that, “along with the other blood tests, we may as well have your PSA level measured to check your prostate”.

In response to this scenario, men indicated how appropriate they thought it would be for the doctor to order a PSA test (“very inappropriate”, “inappropriate”, “appropriate” or “very appropriate”).

Our second scenario also described a GP ordering a PSA test, but the GP did not disclose to the patient that the test was being ordered:

Scenario 2 (‘undisclosed’ opportunistic PSA screening):

Now imagine that the doctor did not ask Mr A if he wanted a PSA test. So the doctor has gone ahead and ordered a PSA test along with the other blood tests without telling Mr A.

As for Scenario 1, men were asked to rate the GP’s behaviour on the same four-point scale of appropriateness.

Statistical analysis

For each scenario, we compared characteristics of men who indicated testing was “very inappropriate” or “inappropriate” with those who indicated it was “very appropriate” or “appropriate”. Wilcoxon signed rank tests were applied to conduct within-group comparisons of men’s responses to each of the scenarios. Multivariate analyses were conducted to determine significant and independent predictors of negative reactions (“very inappropriate” or “inappropriate”) to each scenario. Variables univariately associated with outcomes at the P < 0.25 level were selected for entry into multivariate models.17 Analyses were conducted using SPSS software.18

With respect to sample size, we had estimated that we would need to contact 7000 households in order to yield 500 interviews.19 A sample size of 500 was sufficient to estimate proportions so that 95% CIs for these estimates did not exceed ± 5% of the true value. This sample size also was sufficient to conduct subgroup comparisons of responses between men on categorical predictor variables with a power of 0.80 and an alpha level of 0.05.

Ethics approval

Our study was approved by the Central Sydney Area Health Service Ethics Review Committee.

Results

As reported in detail elsewhere,14,15 we identified 585 potential respondents. Of these, 521 consented to take part (raw response fraction, 89.1%). Of these, seven were found to have had a previous diagnosis of prostate cancer and their responses were excluded. This left a final sample size of 514 respondents.

Selected characteristics of the participants are shown in Box 1. The age distribution of the sample was not statistically different from that of the population of men defining the sampling frame.14 The majority of men were married or living as married (n = 385; 74.9%), were currently employed (n = 361; 70.2%), and usually spoke English at home (n = 448; 87.2%). Just over a third held a university qualification (n = 192; 37.4%).

With respect to men’s preferences for decisional control regarding PSA screening, 173 (33.7%) preferred an “active” role, while 117 (22.8%) preferred a “passive” role. Men answered, on average, 29% of the 14 knowledge questions correctly.

Scenario-based assessment of men’s reactions to “disclosed” or “undisclosed” PSA screening

Men’s reactions to the two scenarios are shown in Box 2. In response to Scenario 1, over 90% (n = 486; 94.6%) of men stated that it was either “appropriate” or “very appropriate” for the GP to include PSA screening among other serological tests. In response to Scenario 2, in which the intention to include a PSA test was not disclosed, fewer than half the respondents (n = 231; 44.9%) considered this approach “appropriate” or “very appropriate”. The difference in responses to the two scenarios was statistically significant (P < 0.001).

Independent predictors of men’s reactions to “disclosed” or “undisclosed” PSA screening

The skewed distribution of responses to Scenario 1 precluded multivariate analysis. However, it was possible to undertake this analysis for Scenario 2. Three respondent characteristics were significant and independent predictors of negative reactions to “undisclosed” PSA screening: younger age (adjusted odds ratio [AOR], 0.97; 95% CI, 0.94–1.00; P = 0.03); greater knowledge about prostate cancer and PSA screening (AOR, 1.01; 95% CI, 1.00–1.03; P = 0.02); and being unmarried (AOR = 0.62; 95% CI, 0.41–0.94; P = 0.02) (Box 3). Variables that were not predictive included men’s preferences for involvement in PSA screening decisions, health locus of control, and self-reported health status.

Discussion

To our knowledge, our study is the first to compare men’s views about “disclosed” and “undisclosed” PSA screening. An overwhelming majority endorsed “disclosed” PSA screening if a GP elected to initiate its inclusion among a battery of serological tests. Ransohoff et al have speculated that GPs are positively reinforced for ordering tests that may potentially diagnose asymptomatic cancer,23 irrespective of the risks involved in such testing. “Undisclosed” inclusion of PSA screening within a battery of tests was significantly more likely to be rejected by the respondents, although nearly half remained convinced of its appropriateness. It would seem that a sizeable proportion of men respect GPs for taking the initiative, regardless of the extent to which GPs give them sufficient information to make an “informed decision”. Younger men were significantly less likely to endorse such an approach, suggesting that older men may be more willing to acquiesce to “paternalistic” GP behaviour and may be more accepting of it.24,25 Older men may also feel more vulnerable about prostate cancer. Men exhibiting more accurate knowledge about prostate cancer and the pros and cons of its early detection were less likely to endorse Scenario 2. “Undisclosed” screening may be less acceptable to men the more aware they become of the scientific uncertainty about the efficacy of PSA screening and the potential adverse consequences of screening.

As decision aids foster patient empowerment as well as improve knowledge,14,26 their wider use might change men’s views about “disclosure” more generally. On the other hand, some level of support for opportunistic screening may persist, even with more transparent discussions between GPs and patients of the pros and cons of screening. While some have conceptualised the decision whether to undergo PSA screening as a “toss-up” between a possible extended life and possible harms of screening,27 some men may always place greater weight on improved life expectancy. While we tried to ensure that our knowledge test assessed men’s knowledge of both the pros and cons of PSA screening, we accept that there is no “gold standard” for such measures and others may seek to emphasise different aspects.

The high response rate and random selection of participants from the community are strengths of our study. However, as the sample was recruited from an urban area, the findings may not be generaliseable to all Australian men. While order effects within our CATIs may also have biased our results, the shift in men’s views from Scenario 1 to Scenario 2 was substantial, suggesting our findings were not produced by artefacts in study design.

In future research, we recommend that scenarios could be posed in which GPs are depicted as either informing or not informing men of the pros and cons of PSA screening. Other scenarios could elicit views about various methods to assist men to make an informed choice, including consent forms, mandatory disclosure (as required for HIV testing) or “cooling-off” periods (during which patients are advised to take time to think over their decision). Educating men about the pros and cons of screening may alter their support of opportunistic screening and thus enhance community expectations of the “informed participation” recommended by health authorities.

1 Selected characteristics of participants (n = 514) (figures represent number [%] of men, except where otherwise specified)

Self-reported health status20

    Excellent

98 (19.1%)

    Good

283 (55.1%)

    Fair

107 (20.8%)

    Poor

26 (5.1%)

Current smoker

    Yes

82 (16.0%)

Previous heart attack or stroke

    Yes

44 (8.6%)

Control preferences scale (for PSA screening decisions)16

    Passive

117 (22.8%)

    Shared/collaborative

222 (43.2%)

    Active

173 (33.7%)

    Unsure

2 (0.4%)

Knowledge about prostate cancer and PSA screening*

    Mean (SD)

29% (16.3%)

    Median (interquartile range)

29% (14%–36%)

Health locus of control scale21,22

    Mean (SD)

3.3 (0.93)

    Median (interquartile range)

3.3 (2.7–4.0)


PSA = prostate-specific antigen. * Based on answers to 14 questions, converted to a score out of 100.14

2 Participant responses to two scenarios describing a general practitioner opportunistically ordering a PSA screening test

Scenario 1 (“disclosed” opportunistic PSA screening)

    Very inappropriate

5 (1.0%)

    Inappropriate

16 (3.1%)

    Appropriate

197 (38.3%)

    Very appropriate

289 (56.2%)

    Don’t know/can’t say

7 (1.4%)


Scenario 2 (“undisclosed” opportunistic PSA screening)

    Very inappropriate

107 (20.8%)

    Inappropriate

166 (32.3%)

    Appropriate

171 (33.3%)

    Very appropriate

60 (11.7%)

    Don’t know/can’t say

10 (1.9%)


PSA = prostate-specific antigen.

3 Significant and independent predictors of the response that opportunistic ordering by GPs of “undisclosed” PSA screening tests is “inappropriate” or “very inappropriate” (Scenario 2)*

Proportion of men responding “inappropriate” or “very inappropriate”

Adjusted odds ratio (95% CI)

P


Marital status

    Married/living as married (n = 377)

51.2%

0.62 (0.41–0.94)

0.02

    Single (n = 126)

62.3%

1.00

Age

0.97 (0.94–1.00)

0.03

    50–54 (n = 173)

59.0%

1.67 (1.01–2.82)

    55–59 (n = 133)

55.6%

1.57 (0.92–2.70)

    60–64 (n = 104)

51.0%

1.22 (0.70–2.16)

    65–70 (n = 93)

46.2%

1.00

Knowledge about prostate cancer and PSA screening (14-item measure)14

1.01 (1.00–1.03)

0.02

    50% correct (n = 432)

52.1%

1.84 (1.08–3.14)

    > 50% correct (n = 71)

66.2%

1.00


GP = general practitioner. PSA = prostate-specific antigen. *11 (2.1%) respondents were excluded from the analysis because of missing or “don’t know” responses. Modelled as continuous.

Received 28 October 2004, accepted 7 February 2005

  • Melina Gattellari1
  • Jeanette E Ward2

  • 1 School of Public Health and Community Medicine, University of New South Wales, Liverpool, NSW.
  • 2 Division of Population Health, South Western Sydney Area Health Service, Liverpool, NSW.

Correspondence: 

Acknowledgements: 

We would like to thank the men who freely gave their time to participate in this study, and Andrew Searles, Helen Beddow and David Shellard from the Hunter Valley Research Foundation, for CATI services.

Competing interests:

None identified.

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