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Tremor syndrome associated with a fungal toxin: sequelae of food contamination

Med J Aust 2005; 182 (11): 582-584.

We report on an elderly couple who presented with a syndrome that included severe generalised tremor and incoordination after eating soup from a damaged can. Black mould contaminating the can was subcultured and the fungus Penicillium crustosum was identified. This fungus usually produces a potent neurotoxin called penitrem A. The couple displayed symptoms consistent with penitrem A ingestion, all of which resolved fully. Penitrem A intoxication has been well documented in animals, but not in humans.

An elderly couple was admitted to hospital after sudden onset of severe muscle tremors. The husband (aged 89) and wife (aged 84) described an uneventful morning. At about 12:00, they had shared a can of soup and toast, followed by chocolate cake, before catching a bus to the local shopping centre. They noticed the soup had a bitter taste, but dismissed the finding because it was a new brand and type to them. There had been no recent changes to their medications, and no recent exposure to garden sprays, insecticides or pesticides.

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  • Peter R Lewis1
  • Michael B Donoghue2
  • Lucy Cook3
  • Linda V Granger4
  • Ailsa D Hocking5

  • 1 Central Coast Health, Gosford, NSW.
  • 2 Food Science Australia, CSIRO, North Ryde, NSW.

Correspondence: 

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