Connect
MJA
MJA

eMJA: In other journals - 15 April 2002

Med J Aust 2002; 176 (8): 398.
Published online: 15 April 2002

A subgroup analysis of the Framingham Study found a strong association between homocysteine and the risk of dementia. The association appears to be independent of age, sex, APOE genotype, plasma vitamin levels and other putative risk factors for dementia. At their 20th biennial follow-up, 1092 dementia-free subjects had their plasma homocysteine levels measured. Over a median follow-up period of 8 years, 111 subjects developed dementia. Those with a plasma homocysteine level >14 µmol/L had almost twice the risk of those with lower levels. Vitamin therapy with folic acid, alone or with vitamins B12 and B6, can reduce plasma homocysteine levels. Prospective trials will be required to demonstrate if vitamin B supplements will reduce the risk of dementia.



Correspondence: 

Author

remove_circle_outline Delete Author
add_circle_outline Add Author

Comment
Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Responses are now closed for this article.