eMJA: In other journals - 17 June 2002

Med J Aust 2002; 176 (12): . || doi: 10.5694/j.1326-5377.2002.tb04596.x
Published online: 17 June 2002

New evidence from experimental mice further supports the idea that the early postnatal period is a critical time for establishing lifelong anxiety behaviour. The findings implicate serotonin, known to be important in mood regulation, with its agonists used therapeutically in humans as anxiolytics. American scientists had previously shown that mice bred with no serotonin-1A receptors (5-HT1AR knockouts) were more “anxious” than wild mice on three standard tests (eg, in a novel environment they took longer to start eating). In a new transgenic mouse, it is possible to turn off the expression of these serotonin receptors at will by feeding the mouse doxycycline. Researchers found that mice fed doxycycline to switch off the receptors during the embryonic and early postnatal period developed pronounced anxiety as adults (similar to 5-HT1AR knockouts). Mice fed doxycycline as adults were not affected.



remove_circle_outline Delete Author
add_circle_outline Add Author

Do you have any competing interests to declare? *

I/we agree to assign copyright to the Medical Journal of Australia and agree to the Conditions of publication *
I/we agree to the Terms of use of the Medical Journal of Australia *
Email me when people comment on this article

Online responses are no longer available. Please refer to our instructions for authors page for more information.