Ceftriaxone and cefotaxime use in Victorian hospitals

Marion B Robertson, Jonathan G A Dartnell, Tony M Korman, Lisa L Ioannides-Demos, Sue W Kirsa, Julie A V Lord, Liliana Munafo and Graham B Byrnes
Med J Aust 2002; 176 (11): 524-529. || doi: 10.5694/j.1326-5377.2002.tb04549.x
Published online: 3 June 2002


Objective: To determine patterns of use of ceftriaxone and cefotaxime (CEFX) in Victorian hospitals and to identify areas for improvement.

Design, patients and setting: A concurrent, observational evaluation of CEFX use in patients commencing a course of these drugs between 8 and 14 September, 1999, in 51 Victorian hospitals.

Main outcome measures: Proportion of patients treated with CEFX; indications; duration of use; concordance with recommendations of national antibiotic guidelines (Therapeutic guidelines: antibiotic, 10th edition [AG10]).

Results: 671 patients were treated with CEFX. The overall rate of use was 43 patients per 1000 inpatient separations. Treatment of respiratory tract infection accounted for 352 patients (52%) and surgical prophylaxis for 99 patients (15%). Treatment of skin/soft tissue, urinary tract and gastrointestinal tract infections accounted for about 7% of patients each. The median duration of CEFX courses was 3.0 days. The overall rate of concordance with indications recommended in AG10 was 27%. The rate of concordance for empirical treatment of respiratory tract infection was 24%. Of the 195 patients treated empirically with CEFX for community-acquired respiratory tract infection and assessed as non-concordant, 64% did not have radiological evidence of pneumonia, and a further 30% did not fulfill the criteria for severe pneumonia. All courses given for surgical prophylaxis were non-concordant.

Conclusions: CEFX is widely used in Victorian hospitals, mostly to treat lower respiratory tract infection and in surgical prophylaxis of infection. The rate of concordance with AG10 is low. Potential areas for intervention include empirical treatment of respiratory tract infection and use in surgical prophylaxis.

In the United States, use of broad-spectrum cephalosporins has been linked to the emergence of vancomycin-resistant enterococci (VRE) and penicillin-resistant streptococci.1,2

VRE was first isolated in Australia in 1994, and since then there has been a steady increase in the number of reports of VRE throughout the country.3 Broad-spectrum cephalosporins are widely used in Victorian hospitals, and small studies have found that much broad-spectrum cephalosporin use is not concordant with national prescribing guidelines.4 Following on from a conference on vancomycin-resistant enterococci, where the results of a previous multisite study of vancomycin use were presented,5 broad-spectrum cephalosporins were identified as a particular target for use evaluation and antibiotic "stewardship". We therefore undertook this study to determine patterns of use of ceftriaxone and cefotaxime (CEFX) in Victorian hospitals, and to identify areas for improvement.


All 77 Victorian hospitals that employed a pharmacist listed on the database of the Society of Hospital Pharmacists of Australia (SHPA) were invited to participate. All patients at participating hospitals who started a course of CEFX between 8 September and 14 September, 1999, inclusive, were eligible for enrolment.

Pharmacists at each hospital collected the following data:

Each hospital provided details of the hospital's antibiotic policy and the number of inpatient separations between 8 and 14 September, 1999. Five major metropolitan teaching hospitals also provided information about the number of separations and occupied bed-days for medical and surgical inpatients.

We used algorithms specific for site of infection to assess all courses (except those for specific treatment) for concordance with AG10 recommendations. The final assessment represented the consensus of three assessors (two pharmacists and an infectious diseases physician) working together.

For the purposes of analysis we considered inpatient separations as the unit of interest. We report the proportion of inpatient separations where patients received at least one course of CEFX and the proportion where patients received at least one course concordant with AG10 recommendations. Definitions of terms are given in Box 1.

Statistical analysis

Analysis was by grouped logistic regression, using the "glm" command in STATA version 7.0.7 This allowed the assessment of model fit, as well as the significance of individual explanatory variables. Hypothesis testing used the likelihood ratio test (χ2 value given), or Wald test (odds ratio [OR] and 95% confidence interval [CI] given), as appropriate.

Concordance for patients treated for respiratory tract infection

Box 3 summarises the AG10 recommendations for use of CEFX in RTI, and our findings in relation to these recommendations are shown in Box 4. The indication was concordant for 78 (29%) of 273 patients treated for community-acquired RTI and 8 (10%) of 79 patients treated for hospital-acquired RTI. Most were assessed as non-concordant because there was no chest x-ray evidence of pneumonia (45% of patients treated for community-acquired infections and 33% of patients treated for hospital-acquired infections). A further 22% of patients treated for community-acquired RTI had non-concordant indications because none of the indicators for severe pneumonia were present.

Of the 74 patients treated for severe community-acquired pneumonia, the indication and overall regimen were concordant for 12 (16%). The main reason for non-concordance was the omission of intravenous (IV) erythromycin from the regimen (60 patients, including 24 who were treated with oral roxithromycin instead of IV erythromycin).

For 37 (11%) of the 352 patients with RTI, there was no documentation as to whether a chest x-ray had been done, or the results of the x-ray or indicators of the severity of pneumonia were not recorded. If these cases are counted as appropriate indications for CEFX, concordance increases from 29% to 37% for community-acquired infections and remains the same for hospital-acquired infection.

Comparison of all hospitals

CEFX use: This varied significantly between Victorian hospitals overall (χ2 = 219; df = 50; P <0.0001). The 13 hospitals with restrictive policies did not have significantly lower proportions of CEFX use than those without (OR, 0.90; 95% CI, 0.77–1.05). In addition, the variables "private v public" and "regional v metropolitan" were not significant explanatory factors. None of the collected parameters were adequate to explain the interhospital variation in use, emphasising the contribution of casemix and other hospital-specific factors.

Concordance: The proportion of patients treated in concordance with AG10 recommendations differed significantly between hospitals (χ2 = 72; df = 47; P = 0.011). Concordance was significantly lower in private hospitals (OR, 0.49; 95% CI, 0.28–0.87). Use for surgical prophylaxis was high in private hospitals, accounting for 29% of the patients treated compared with 12% in public hospitals. Concordance in the 13 hospitals with restrictive policies was 29%, and was not significantly higher than in hospitals without restrictive policies (OR, 1.24; 95% CI, 0.88–1.76).

Three Victorian hospitals did not have any patients treated with CEFX and these hospitals were omitted from our dataset. The effect of the variable "metropolitan v regional" was not significant (OR, 1.3; 95% CI, 0.95–2.07), nor was there evidence of interaction. Examining residuals for the model suggested that one hospital should be omitted from the data, having none of 13 patients treated in concordance with recommendations. With this hospital removed, the single factor "private v public" adequately explained the variation in proportion of concordance across the 47 remaining hospitals (goodness-of-fit test, χ2 = 48.0; df = 43; P = 0.28). The OR for "private v public" was little changed by this omission (OR, 0.46; 95% CI, 0.26–0.82).

Comparison of the five major teaching hospitals

CEFX use: A comparison of the five major metropolitan teaching hospitals is shown in Box 5. Within these, CEFX use was significantly higher in the hospital without a restrictive policy (Hospital 1) (OR, 1.82; 95% CI, 1.37–2.42). However, this should be interpreted with caution, for several reasons. Firstly, the four hospitals with restrictive policies were significantly inhomogeneous (χ2 = 14.7; df = 3; P = 0.002), so pooling them for the purpose of comparison may not be valid. Secondly, the data could be explained by division into two groups: "high" CEFX users (Hospitals 1, 2, and 4) and "low" CEFX users (χ2 = 4.85; df = 1; P = 0.18). Adding "restrictive policy" to this model did not result in a significant improvement (χ2 = 3.28; df = 1; P = 0.07). Further, Hospital 1 did not have significantly higher use of CEFX than the other "high"-use hospitals (OR, 1.34; 95% CI, 0.98–1.85). Thirdly, as only one of these hospitals did not have a restrictive policy (Hospital 1), higher use might have been the result of other factors specific to the hospital.

Concordance: Among the five major teaching hospitals, "hospital" was not a significant factor in predicting concordance (χ2 = 5.92; df = 4; P = 0.21). In particular, the hospital without a restrictive prescribing policy (Hospital 1) was not significantly different from those with restrictive policies (OR, 0.83; 95% CI, 0.45–1.55). Use for surgical prophylaxis was high in Hospitals 1 and 2 and low in Hospitals 3, 4 and 5.


We found extensive inappropriate use of CEFX in Victorian hospitals of all sizes. Our sample was large, representing 74% of all public hospital, but only 24% of all private hospital, inpatient separations in Victoria during the study period.

The rate of use varied significantly between hospitals, but this was not explained by whether hospitals were public, private, metropolitan, regional, or whether or not they had restrictive antibiotic policies. We compared use with recommendations in national antibiotic prescribing guidelines (AG10) and found that the indications for more than 70% of patients were not in concordance with the recommendations.

Potential limitations of our study are (i) the participating hospitals may not have been representative of all Victorian hospitals; (ii) a limited set of data and objective criteria was used to assess the indication for use and may not have accurately represented the reason for use and the condition of the patient in all cases; (iii) the study focused on the use of CEFX for all indications, but did not evaluate the use of other antibiotics for those indications; and (iv) use of CEFX was compared with prescribing guidelines, which cannot provide appropriate advice for all patients.

Empirical treatment of RTI accounted for about half of all patients given CEFX. An important finding for educators is that most courses in these patients (76%) were non-concordant with AG10 guidelines because basic criteria were not met, such as chest x-ray evidence of pneumonia. It is relevant to note that in the most recent (11th) edition of the Therapeutic guidelines: antibiotic,8 the recommendation for use of CEFX in the treatment of severe community-acquired pneumonia has been further restricted to patients who are hypersensitive to penicillin. Fewer courses would be considered concordant if compared with the more recent edition.

The second most frequent indication for CEFX was for surgical prophylaxis (15% of courses), despite not being recommended for surgical prophylaxis in AG10, and receiving limited mention, if any, in other authoritative guidelines.9,10 However, surgical prophylaxis is a registered indication in product information for CEFX, and these drugs can be promoted by their manufacturers for this use. Such inconsistencies are clearly problematic.

We presented our results to a multihospital, multidisciplinary forum as well as to the participating hospitals.11 Hospitals are responding to the findings individually, in ways such as removing CEFX from operating theatres and implementing interactive checklists on computer-based approval systems. The concerns are unanimous: continuing inappropriate use of CEFX will result in increasing antimicrobial resistance.

We believe a coordinated, sustained and iterative approach is needed to effectively monitor and improve hospital use of antibiotics. Drug audits like this one, which involve transcribing information from medical records, are laborious and time-consuming. The information systems in Victorian hospitals are inadequate, both in terms of tracking how patients are managed and in supporting clinicians in clinical decision making. Data on drug use are not linked to patients, indications or prescribers, let alone clinical outcomes. Clinical information is generally not available at the point of decision making. To achieve quality use of antibiotics, both data linkage and provision of clinical information are needed.

3: Summary of Therapeutic guidelines: antibiotic, 10th edition,6 recommendations for the treatment of respiratory tract infection

CEFX is recommended for the empirical treatment of:

  • acute epiglottitis;

  • severe community-acquired pneumonia;

  • mild to moderate hospital-acquired pneumonia in patients hypersensitive to penicillin or with significant renal failure; and

  • severe early-onset hospital-acquired pneumonia

Severe pneumonia: In adults, is defined by the presence of one or more of the following, not attributable to another cause: respiratory rate, > 30/min; diastolic blood pressure, < 60 mmHg; systolic blood pressure, < 90 mmHg; evidence on chest x-ray of bilateral involvement or involvement of multiple lobes; increase in the size of chest x-ray opacity by 50% or more within 48 hours of admission; white blood cell count < 4 × 109/L or > 30 × 109/L; Po2 < 60 mmHg or oxygen saturation < 90% in room air, requirement for mechanical ventilation or Fio2 > 35% to maintain oxygen saturation > 90%; Pco2 > 50 mmHg in room air; confusion; shock; recent deterioration in renal function.

Received 2 May 2001, accepted 13 February 2002

  • Marion B Robertson1
  • Jonathan G A Dartnell2
  • Tony M Korman3
  • Lisa L Ioannides-Demos4
  • Sue W Kirsa5
  • Julie A V Lord6
  • Liliana Munafo7
  • Graham B Byrnes8

  • 1 Department of Clinical Pharmacology and Therapeutics, Melbourne, VIC.
  • 2 Monash Medical Centre, Melbourne, VIC.
  • 3 Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC.
  • 4 Austin and Repatriation Medical Centre, Melbourne, VIC.
  • 5 St Vincent's Hospital, Melbourne, VIC.
  • 6 The Alfred Hospital, Melbourne, VIC.
  • 7 Department of Mathematics and Statistics, University of Melbourne, Melbourne, VIC.



This project resulted from the collaborative work of the Victorian Drug Usage Evaluation Group, the Victorian Drug Usage Advisory Committee and the Standing Committee on Infection Control. It has been supported financially by the Victorian Department of Human Services and administered by the Victorian Drug Usage Advisory Committee. We recognise the dedicated work of the pharmacists responsible for the data collection. We acknowledge the assistance of the other members of the Victorian Drug Usage Evaluation Group in this study: Dr Jo-anne E Brien, Ms Sylvia Cuell, Mr Geoffrey E Davies, Dr Natalie J Hetherington, Ms Anne Leversha, Mrs Roslyn I McKinnon, Associate Professor Robert FW Moulds, Ms Susan G Poole, and Dr Gail J Ware. We thank Mr Gregory M Saville and Dr Lachlan Macgregor for assistance with the statistical analysis.

Competing interests:

We have no competing interests, and the funding body (the Victorian Department of Human Services) was not involved in the design of the study, the collection, analysis or interpretation of data, the writing of the article, or the decision to submit the final manuscript for publication.

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