The bioactive lipids responsible for the signs and symptoms of inflammation belong mainly to the omega-6 family and are represented by prostaglandins and leukotrienes. Antagonism of inflammation by omega-3 fatty acids has been demonstrated in animal models. Studies have shown that omega-3 fatty acids, particularly those in fish oil, can decrease leukocyte production of omega-6 prostaglandins and leukotrienes, as well as cytokines.1
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