MJA InSight
MJA Careers
EBM: Trials on trial

Which substitution pharmacotherapy is most effective in treating opioid dependence?

Linda R Gowing, Robert L Ali and Jason M White
Med J Aust 2002; 176 (10): 493-494.

Are levo acetyl methadol (LAAM) and buprenorphine as effective as methadone for substitution treatment of opioid dependence?

Trial details


Randomised controlled trial, double-blind.


Outpatient clinic in Baltimore, United States.


Linda R Gowing, PhD, Manager, Evidence-Based Practice Unit1
Robert L Ali, MB BS, DipRACOG, GDPH, FAFPHM, Director, Clinical Policy and Research2
Jason M White, PhD, Chair in Addiction Studies3
1 Drug and Alcohol Services Council, Parkside, SA.
2 Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA.
Article References: 
Reference Text: 
Diagnostic and statistical manual of mental disorders: DSM-IV. Washington, DC: American Psychiatric Association, 1994.
Reference Order: 
PubMed ID: 
Reference Text: 
Ward J, Mattick RP, Hall W. Methadone maintenance treatment and other opioid replacement therapies. Amsterdam: Harwood Academic Publishers, 1998.
Reference Order: 
PubMed ID: 

The full contents of this page are only available to subscribers.