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Glycaemia and albuminuria as predictors of coronary heart disease in Aboriginal and Torres Strait Islander adults: a north Queensland cohort

Robyn A McDermott, Brad McCulloch and Ming Li
Med J Aust 2011; 194 (10): 514-518. || doi: 10.5694/j.1326-5377.2011.tb03087.x
Published online: 16 May 2011

Abstract

Objective: To evaluate the contribution of non-traditional risk factors to coronary heart disease (CHD) incidence in Indigenous adults.

Design, setting and participants: Cohort study of 1706 Aboriginal and Torres Strait Islander adults from 26 remote communities in far north Queensland who were initially free of CHD, with a mean of 7.5 years of follow-up.

Main outcome measures: CHD-related deaths and hospitalisations obtained by record matching.

Results: CHD incidence was similar in men and women and in Aboriginals and Torres Strait Islanders; overall incidence was 12.1 (95% CI, 10.1–14.1) events per 1000 person-years. At baseline, prevalence of diabetes was 12.4% in Aboriginals and 22.3% in Torres Strait Islanders, prevalence of any albuminuria was similarly high (33.5%) in both groups, and participants with diabetes were 5.5 (95% CI, 4.2–7.3) times more likely to have albuminuria than those without diabetes. At follow-up, adjusted hazard ratios for CHD were 1.7 (95% CI, 1.01–2.8) for obesity based on waist circumference; 1.5 (95% CI, 1.01–2.3) for hypertension; 1.4 (95% CI, 0.9–2.2) for previous or current smoking; 1.9  (95% CI, 1.3–2.7) for elevated triglycerides; 1.3 (95% CI, 0.9–1.9) for low high-density lipoprotein cholesterol; 1.3 (95% CI, 0.8–2.2) for impaired fasting glucose; 2.4 (95% CI, 1.7–3.5) for diabetes; and 4.6 (95% CI, 2.9–7.1) for macroalbuminuria. Baseline albuminuria without diabetes increased risk by 50% (adjusted rate ratio, 1.5 [95% CI, 0.9–2.4]) but diabetes with macroalbuminuria amplified risk sixfold (adjusted rate ratio, 5.9 [95% CI, 3.4–10.1]).

Conclusion: High prevalence of glycaemia and albuminuria in this population, especially when combined, account for much of the excess CHD risk beyond the traditional Framingham risk factors. They can be measured simply, lend themselves to cardioprotective interventions, and should be used routinely to estimate risk and monitor effectiveness of treatment.

Methods
Participants

The Well Person’s Health Check (WPHC), conducted between 1998 and 2000, offered screening and referral services for people in 26 remote Indigenous communities in far north Queensland.5 Of the 2862 Aboriginal and Torres Strait Islander participants aged 15 years and over, 2506 (87.6%) consented to be recontacted for future checks and access to their health records. The study was approved by the Cairns Base Hospital Ethics Committee with support from Apunipima Cape York Health Council and the Torres Strait and Northern Peninsula Area Health Council.

Baseline measurements

Details of the methods used in the WPHC have been published elsewhere.6 Participants underwent anthropometric assessment, including measurement of waist circumference at the level of the umbilicus. Tobacco smoking and alcohol intake data were collected by a self-report questionnaire. Levels of total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglycerides and glucose were measured from blood collected in the early morning after at least 8 hours of fasting. Blood glucose and lipid levels were measured by photometric enzyme end point assay, using the Cobas Integra 700 and 400 (Roche Diagnostics, New York, NY, USA). Urinary albumin-to-creatinine ratio (UACR) testing was performed routinely by immunoassay on all urine specimens that were collected in a sterile 50 mL container and refrigerated immediately following collection. Sitting blood pressure data were obtained by averaging three measurements taken after 10 minutes rest.

Results

Included in the final analysis were 1706 adults who had complete baseline data and whose records were matched. Of the 2506 WPHC participants who consented to be recontacted, 800 were excluded: 147 were not free of CHD at baseline, 508 had incomplete baseline clinical data, and 145 were of non-Indigenous or mixed Indigenous descent. There was no substantial difference in age and sex between those excluded and those included. Baseline characteristics of the study population are summarised in Box 1. There were about equal numbers of men and women. The women were slightly older than the men and had a higher prevalence of diabetes. Compared with Aboriginal participants, Torres Strait Islanders were slightly older, had substantially higher BMI, had higher fasting glucose and nearly double the prevalence of diabetes, and had lower smoking rates. Baseline prevalence of diabetes was 12.4% (126/1020) in Aboriginals and 22.3% (153/686) in Torres Strait Islanders, whereas prevalence of any albuminuria (UACR, > 3.4) was similarly high (572/1706, 33.5%) in both groups. At baseline, those with diabetes were 5.5 (95% CI, 4.2–7.3) times more likely to have albuminuria than those without diabetes.

One hundred and twenty-one CHD events (deaths and hospitalisations) were recorded in 10 022 person-years of follow-up (Box 2). Incidence of CHD was similar in men and women, and in Aboriginals and Torres Strait Islanders, with an overall incidence rate of 12.1 (95% CI, 10.1–14.1) events per 1000 person-years. Rates increased with age, but there was substantial illness (14 events) in participants aged 15–34 years at baseline.

Because baseline risk categories tracked with age and differed by sex, hazard ratios were adjusted for age and sex (Box 3). Further adjustment for ethnicity did not alter the results. Adjusted hazard ratios for CHD were 1.7 (95% CI, 1.01–2.8) for obesity based on waist circumference; 1.5 (95% CI, 1.01–2.3) for hypertension; 1.4 (95% CI, 0.9–2.2) for previous or current smoking; 1.9 (95% CI, 1.3–2.7) for elevated triglycerides; 1.3 (95% CI, 0.9–1.9) for low HDL-C (< 1.0 mmol/L); 1.3 (95% CI, 0.8–2.2) for impaired fasting glucose (5.5–6.9 mmol/L); 2.4 (95% CI, 1.7–3.5) for diabetes; and 4.6 (95% CI, 2.9–7.1) for macroalbuminuria (UACR ≥ 34). Crude hazard ratio increased with increasing baseline fasting glucose from a threshold of about 5.0 mmol/L but this effect was attenuated after adjustment for age and sex (Box 3).

The Framingham risk factors (BMI, smoking status, blood pressure and hyperlipidaemia) each increased the age-adjusted CHD risk by less than twofold. The stand-out risk predictors for the study population appeared to be albuminuria and glycaemia, which were highly prevalent at baseline in Aboriginal and Torres Strait Islander participants. Compared with those free of both diabetes and albuminuria at baseline, the age- and sex-adjusted risks for diabetes alone and albuminuria alone (Box 4) were similar to the risk based on traditional Framingham risk factors (adjusted rate ratio, 1.4 [95% CI, 0.9–2.4]). However, diabetes coexisting with microalbuminuria and macroalbuminuria amplified the adjusted rate ratio to 2.3 (95% CI, 1.3–4.2) and 5.9 (95% CI, 3.4–10.1), respectively (Box 4).

Discussion

In our study, the adult population of Indigenous Australians from north Queensland had a very high background prevalence of diabetes and albuminuria and an excess incidence of CHD compared with the non-Indigenous population. Age-specific CHD incidence rates were similar for men and women, and for Aboriginals and Torres Strait Islanders, and comparable to those reported for Aboriginal adults in the Northern Territory and Western Australia.2,3 The higher prevalence of diabetes among women that we observed could explain the lack of sex “protection”, and follows patterns described in other populations where the stronger effect of diabetes in females can be partly explained by a heavier risk factor burden and greater effect of blood pressure and atherogenic dyslipidaemia.7,8 The Strong Heart Study found a similar increased risk of CHD in Native American tribes with similarly high baseline levels of diabetes and albuminuria, and developed a “risk calculator” that takes these factors into account.9

Our study was limited by possible under-identification of matching hospitalisation and death records, as searching was done manually and deaths are often registered late. Also, there was potential for miscoding of hospital separation data and cause of death in routine collections. However, as most of the communities included were small, we could verify most deaths, including cause of death, from local clinical records and staff.

Our finding that a glycaemia threshold lower than that for a diagnosis of diabetes also increases CHD risk in the study population accords with data from other, larger studies. A meta-analysis of 38 prospective studies found a pooled risk ratio of 1.26 (95% CI, 1.11–1.43) for cardiovascular disease end points among non-diabetic subjects with elevated blood glucose regardless of the type of blood glucose assessment.10 The risk was higher in cohorts including women than in cohorts of men, and the analysis suggested a threshold effect of fasting glucose of 5.6 mmol/L, which supports the revised criteria for the diagnosis of impaired fasting glucose by the American Diabetes Association.11 A pooled analysis of 17 Asian and Australian cohorts found a threshold of 4.9 mmol/L; overall, there was a 23% lower risk of ischaemic heart disease for each 1 mmol/L lower usual fasting glucose level.12 These analyses suggest that the pathogenic role of hyperglycaemia on blood vessel walls exists in the early stages of glucose intolerance. The effect of postprandial glucose levels in these larger studies seems to be greater than that of fasting glucose, so our estimates may be conservative. The most appropriate targets in management may, therefore, be postprandial glucose or glycated haemoglobin levels.13

In patients with diabetes, increasing albuminuria is associated with marked increases in risk of CHD and all-cause mortality, and reduction in albuminuria during treatment translates to reduction in cardiovascular events.14,15 Similarly, in non-diabetic subjects (with or without elevated glycaemia), reduction in albuminuria translates to reduction in cardiovascular end points.16

The great amplification of CHD risk when impaired fasting glycaemia or diabetes and albuminuria coexist, which we found in our study population, highlights the need for attention to both glycaemia and albuminuria in management plans. High fasting glucose levels and albuminuria found during routine adult health checks should, therefore, be actively managed and monitored, even in the absence of overt diabetes. Reduction in glycaemia and albuminuria should be basic therapeutic goals for CHD risk reduction in high-risk populations such as Indigenous Australians; measures of glycaemia and albuminuria should be routinely reported, in addition to the traditional measures of blood pressure, lipid levels, tobacco smoking and weight.

The challenge we now face is to apply this new knowledge about easy-to-measure clinical predictors of excess CHD incidence in clinical settings, with particular attention to our highest-risk patients — those who have poor access to healthy food, health care services, and other infrastructure and life choices. This includes attending to the needs of the whole person (who may have several serious comorbidities) in a family and community context.

1 Baseline characteristics of the study population, 1998–2000*

Aboriginals


Torres Strait Islanders


Total


Women (n = 534)

Men (n = 486)

Women (n = 324)

Men (n = 362)

Women (n = 858)

Men (n = 848)


Age (years)

38.0 (36.7–39.3)

37.2 (35.9–38.6)

39.8 (38.1–41.6)

38.5 (36.9–40.1)

38.7 (37.6–39.7)

37.8 (36.8–38.8)

BMI (kg/m2)

26.9 (26.2–27.5)

25.0 (24.4–25.5)

33.1 (32.3–33.8)

30.5 (29.9–31.1)

29.2 (28.7–29.7)

27.3 (26.9–27.8)

WC (cm)

94.0 (92.6–95.4)

91.0 (89.6–92.3)

105.6 (103.9–107.4)

102.6 (101.0–104.1)

98.4 (97.3–99.6)

95.9 (94.8–97.0)

Systolic BP (mmHg)

127.0 (125.2–128.8)

132.9 (131.3–134.5)

132.3 (130.0–134.7)

137.8 (136.1–139.5)

129.0 (127.6–130.5)

135.0 (133.8–136.2)

Diastolic BP (mmHg)

70.2 (69.0–71.4)

75.7 (74.4–76.9)

69.0 (67.7–70.4)

74.3 (72.9–75.6)

69.8 (68.9–70.7)

75.1 (74.1–76.0)

Total cholesterol (mmol/L)

4.8 (4.7–4.9)

5.0 (4.9–5.1)

4.9 (4.8–5.0)

5.2 (5.1–5.3)

4.8 (4.7–4.9)

5.1 (5.0–5.2)

Triglycerides (mmol/L)

1.7 (1.6–1.8)

2.1 (1.9–2.3)

1.5 (1.4–1.6)

1.9 (1.7–2.0)

1.6 (1.5–1.7)

2.0 (1.9–2.1)

HDL-C (mmol/L)

1.17 (1.14–1.20)

1.21 (1.17–1.24)

1.10 (1.07–1.13)

1.12 (1.09–1.15)

1.14 (1.12–1.16)

1.17 (1.15–1.19)

Fasting glucose (mmol/L)

5.6 (5.4–5.9)

5.4 (5.2–5.6)

6.3 (5.9–6.6)

6.2 (5.9–6.5)

5.9 (5.7–6.1)

5.8 (5.6–5.9)

UACR

17.3 (11.9–22.8)

13.4 (10.0–16.9)

15.0 (9.4–20.6)

13.9 (9.7–18.0)

16.5 (12.5–20.5)

13.6 (11.0–16.3)

Diabetes, percentage (95% CI)

14.6 (11.6–17.6)

10.3 (7.6–13.0)

24.7 (20.0–29.4)

19.9 (15.8–24.0)

18.4 (15.8–21.1)

14.4 (12.0–16.8)

Smoking (previous and current), percentage (95% CI)

59.2 (55.0–63.4)

71.7 (67.6–75.7)

43.5 (38.1–48.9)

52.1 (46.9–57.2)

53.3 (49.9–56.6)

63.3 (60.0–66.5)


BMI = body mass index.
WC = waist circumference.
BP = blood pressure.
HDL-C = high-density lipoprotein cholesterol.
UACR = urinary albumin-to-creatinine ratio.
* Data are mean (SD) unless otherwise specified.

2 Incidence of coronary heart disease events per 1000 person-years by age at baseline, sex and ethnicity

Aboriginals (n = 1020)


Torres Strait Islanders (n = 686)


Total (N = 1706)


Events

Person-years

Rate (95% CI)

Events

Person-years

Rate (95% CI)

Events

Person-years

Rate (95% CI)


Women and men

15–34 years

10

2 889.3

3.5 (1.9–6.4)

4

1 904.7

2.1 (0.8–5.6)

14

4 794.0

2.9 (1.7–4.9)

35–44 years

14

1 387.9

10.1 (6.0–17.0)

3

787.6

3.8 (1.2–11.8)

17

2 175.6

7.8 (4.9–12.6)

45–54 years

24

839.9

28.6 (19.2–42.6)

17

635.4

26.8 (16.6–43.0)

41

1 475.4

27.8 (20.5–37.7)

55 years

28

921.6

30.4 (21.0–44.0)

21

655.5

32.0 (20.9–49.1)

49

1 577.0

31.1 (23.5–41.1)

Total

76

6 038.7

12.6 (10.1–15.7)

45

3 983.3

11.3 (8.4–15.1)

121

10 022.0

12.1 (10.1–14.1)

Women

15–34 years

6

1 468.4

4.1 (1.8–9.1)

2

904.7

2.2 (0.6–8.8)

8

2 373.1

3.4 (1.7–6.7)

35–44 years

6

712.7

8.4 (3.8–18.7)

2

342.5

5.8 (1.5–23.3)

8

1 055.2

7.6 (3.8–15.2)

45–54 years

12

428.6

28.0 (15.9–49.3)

7

308.7

22.7 (10.8–47.6)

19

737.4

25.8 (16.4–40.4)

55 years

12

523.9

22.9 (13.1–40.3)

10

340.6

29.4 (15.8–54.6)

22

864.5

25.4 (16.8–38.6)

Total

36

3 133.6

11.5 (8.3–15.9)

21

1 896.6

11.1 (7.2–17.0)

57

5 030.1 

11.3 (8.7–14.7)

Men

15–34 years

4

1 420.8

2.8 (1.1–7.5)

2

1 000.1

2.0 (0.5–8.0)

6

2 420.9

2.5 (1.1–5.5)

35–44 years

8

675.3

11.8 (5.9–23.7)

1

445.1

2.2 (0.3–15.9)

9

1 120.4

8.0 (4.1–15.4)

45–54 years

12

411.3

29.2 (16.6–51.4)

10

326.7

30.6 (16.5–56.9)

22

738.0

29.8 (19.6–45.3)

55 years

16

397.7

40.2 (24.6–65.7)

11

314.8

34.9 (19.3–63.1)

27

712.5

37.9 (26.0–55.3)

Total

40

2 905.1

13.8 (10.0–18.8)

24

2 086.7

11.5 (7.7–17.2)

64

4 991.8

12.8 (10.0–16.4)

3 Incidence rate ratios for coronary heart disease (CHD) events by baseline risk factors and ethnicity

Aboriginals (n = 1020)


Torres Strait Islanders (n = 686)


Total (N = 1706)


Crude hazard ratio (95% CI)

Adjusted hazard ratio (95% CI)*

Crude hazard ratio (95% CI)

Adjusted hazard ratio (95% CI)*

Crude hazard ratio (95% CI)

Adjusted hazard ratio (95% CI)*


Body mass index, kg/m2 (reference category, 18.5–24.99)

< 18.5

1.4 (0.6–3.3)

1.5 (0.6–3.6)

2.2 (0.3–18.9)

3.1 (0.3–27.1)

1.4 (0.6–3.2)

1.6 (0.7–3.5)

25–29.99

2.1 (1.2–3.9)

1.8 (1.0–3.4)

1.2 (0.4–3.4)

0.7 (0.2–2.0)

1.8 (1.04–2.9)

1.3 (0.8–2.2)

≥ 30

2.0 (1.1–3.6)

2.1 (1.1–3.8)

1.4 (0.5–3.5)

1.0 (0.4–2.7)

1.7 (1.03–2.7)

1.5 (0.9–2.5)

Waist circumference category (reference category, normal)

Overweight

1.4 (0.6–2.9)

1.4 (0.7–2.9)

1.9 (0.5–7.9)

1.2 (0.3–5.2)

1.4 (0.8–2.8)

1.2 (0.6–2.3)

Obese

2.1 (1.2–3.6)

2.1 (1.1–3.8)

3.1 (0.9–9.9)

1.8 (0.5–6.2)

2.1 (1.3–3.4)

1.7 (1.01–2.8)

Reported or measured hypertension (reference category, no)

Yes

3.6 (2.2–5.9)

2.2 (1.3–3.6)

2.1 (1.1–3.8)

0.8 (0.4–1.6)

2.9 (2.0–4.2)

1.5 (1.01–2.3)

Smoker (reference category, never)

Previous or current

1.2 (0.7–2.3)

1.4 (0.8–2.6)

1.1 (0.5–2.2)

1.3 (0.6–2.7)

1.2 (0.7–1.9)

1.4 (0.9–2.2)

Urinary albumin-to-creatinine ratio (reference category, < 3.4)

3.4–33.9

1.7 (1.0–2.9)

1.1 (0.6–1.9)

4.9 (2.3–10.6)

2.4 (1.1–5.5)

2.4 (1.6–3.7)

1.4 (0.9–2.3)

≥ 34

5.5 (3.2–9.5)

3.2 (1.8–5.7)

13.5 (6.2–29.5)

9.4 (4.3–20.7)

7.4 (4.8–11.3)

4.6 (2.9–7.1)

Fasting glucose quintile, mmol/L (reference category, 1.7–4.4)

4.5–4.7

0.7 (0.3–1.7)

0.8 (0.3–1.9)

0.8 (0.1–4.6)

0.7 (0.1–4.3)

0.7 (0.3–1.5)

0.7 (0.3–1.6)

4.8–5.1

1.3 (0.6–2.7)

1.0 (0.5–2.1)

1.4 (0.3–6.3)

0.9 (0.2–4.3)

1.3 (0.7–2.5)

0.9 (0.5–1.8)

5.2–5.8

1.2 (0.5–2.6)

0.8 (0.4–1.8)

3.0 (0.8–10.9)

1.6 (0.4–6.1)

1.5 (0.8–2.9)

1.0 (0.5–1.9)

≥ 5.9

3.0 (1.6–5.7)

1.8 (0.9–3.5)

6.3 (1.9–21.0)

2.6 (0.8–9.1)

3.6 (2.1–6.1)

1.8 (1.04–3.2)

Fasting glucose category, mmol/L (reference category, < 5.5)

5.5–6.9

2.1 (1.1–3.8)

1.4 (0.7–2.5)

2.6 (1.1–6.4)

1.5 (0.6–3.7)

2.1 (1.3–3.5)

1.3 (0.8–2.2)

≥ 7.0

3.2 (1.8–5.5)

2.1 (1.2–3.7)

6.1 (3.1–12.0)

3.4 (1.7–6.9)

3.9 (2.6–5.9)

2.4 (1.6–3.6)

Diabetes§ (reference category, no)

Yes

3.2 (2.0–5.3)

2.3 (1.4–3.8)

4.8 (2.7–8.7)

3.0 (1.6–5.5)

3.7 (2.5–5.3)

2.4 (1.7–3.5)

High-density lipoprotein cholesterol, mmol/L (reference category, 1.0)

< 1.0

1.4 (0.8–2.3)

1.2 (0.7–2.0)

1.3 (0.7–2.5)

1.3 (0.7–2.5)

1.4 (0.9–2.0)

1.3 (0.9–1.9)

Triglycerides, mmol/L (reference category, < 2.0)

≥ 2.0

2.8 (1.8–4.4)

2.3 (1.5–3.6)

1.5 (0.8–2.8)

1.2 (0.7–2.4)

2.2 (1.5–3.2)

1.9 (1.3–2.7)


* Adjusted for age and sex.
Categories are based on World Health Organization sex-specific criteria.
Analysis includes participants with baseline diabetes.
§ Defined using World Health Organization criteria.
Categories are based on National Heart Foundation and Australian Diabetes Society recommendations.


Provenance: Not commissioned; externally peer reviewed.

  • Robyn A McDermott1
  • Brad McCulloch2
  • Ming Li1

  • 1 Sansom Institute for Health Research, University of South Australia, Adelaide, SA.
  • 2 Tropical Public Health Unit, Queensland Health, Cairns, QLD.



Acknowledgements: 

This study was supported partly by National Health and Medical Research Council Project Grant Number 279402. Our thanks also to Queensland Health staff for assistance with data collection and record linkage.

Competing interests:

None identified.

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