eMJA: Characterising novel pathways to schizophrenia

Supplement

Characterising novel pathways to schizophrenia

Ian B Hickie and Patrick D McGorry

MJA 2009; 190 (4): S5-S6

New approaches to schizophrenia research and policy can provide a substantive basis for early intervention and better care

For the past 20 years, much of the clinical and basic science research related to schizophrenia has been based on the belief that the disorder results largely from genetically determined abnormalities in brain development.1,2 Although some perinatal factors (eg, intrauterine infection and hypoxia during labour) have been conceded, they are still considered within the constraints of the neurodevelopmental model. Against this background of “genetic developmentalism”, preventive and early intervention strategies have often been discounted. Further, this nihilistic view has been reinforced by major gaps in clinical care,3 partial response to pharmacological or psychosocial interventions,4 and premature deaths from suicide, injury and vascular disease.5

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