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Research integrity and pharmaceutical industry sponsorship

Peter C Gøtzsche
Med J Aust 2005; 182 (11): . || doi: 10.5694/j.1326-5377.2005.tb06807.x
Published online: 6 June 2005

Trial registration, transparency and less reliance on industry trials are essential

Over the past 20 years, politicians, hospital administrators and university deans have encouraged academic researchers to increase their participation in projects sponsored by the pharmaceutical industry, and the industry’s share of biomedical research has increased dramatically in that time (from 32% to 62% in the United States).1 Increasingly, the wisdom of this development has been challenged.


  • Nordic Cochrane Centre, Copenhagen, Denmark.


Correspondence: 

Competing interests:

None identified.

  • 1. Bekelman JE, Li Y, Gross CP. Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA 2003; 289: 454-465.
  • 2. Johansen HK, Gøtzsche PC. Problems in the design and reporting of trials of antifungal agents encountered during meta-analysis. JAMA 1999; 282: 1752-1759.
  • 3. Safer DJ. Design and reporting modifications in industry-sponsored comparative psychopharmacology trials. J Nerv Ment Dis 2002; 190: 583-592.
  • 4. Als-Nielsen B, Chen W, Gluud C, Kjaergard LL. Association of funding and conclusions in randomized drug trials: a reflection of treatment effect or adverse events? JAMA 2003; 290: 921-928.
  • 5. Chan A-W, Hróbjartsson A, Haahr MT, et al. Empirical evidence for selective reporting of outcomes in randomized trials. JAMA 2004; 291: 2457-2465.
  • 6. Konstam MA, Weir MR, Reicin A, et al. Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib. Circulation 2001; 104: 2280-2288.
  • 7. Jüni P, Nartey L, Reichenbach S, et a.l Risk of cardiovascular events and rofecoxib: cumulative meta-analysis. Lancet 2004; 364: 2021-2029.
  • 8. Henry DA, Kerridge IH, Hill SR, et al. Medical specialists and pharmaceutical industry-sponsored research: a survey of the Australian experience. Med J Aust 2005; 182: 557-560. <MJA full text>
  • 9. Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Available at: http://www.icmje.org/clin_trial.pdf (accessed Apr 2005).
  • 10. Gøtzsche PC. Blinding during data analysis and writing of manuscripts. Control Clin Trials 1996; 17: 285-290.
  • 11. ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981-2997.

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