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The road to consensus: considerations for the safe use and prescribing of COX-2-specific inhibitors

Agnes I Vitry and Eve Hurley
Med J Aust 2002; 177 (10): . || doi: 10.5694/j.1326-5377.2002.tb04959.x
Published online: 18 November 2002

To the Editor: Regarding the position statement about COX-2 inhibitors, we agree that openness about all potential conflicts of interest is the least we should expect from guideline developers, but this is not enough.1 Fifteen (65%) of the 23 members of the Australian COX-2 Specific Inhibitor Prescribing Group (including all eight of the rheumatologists involved) declared current financial links with Pfizer and Merck, Sharp and Dohme, the two drug companies marketing COX-2 inhibitors in Australia.2 The Prescribing Group can be viewed at best as a tight collaboration between some healthcare professionals and drug companies. At worst the statement published in the Journal can be seen as the "happy end" of a successful marketing campaign, which began some years ago with the enrolment of the most influential Australian rheumatologists to the advisory boards of the drug companies.3




Correspondence: agnes.vitry@unisa.edu.au

  • 1. Edmonds JP, Day RO, Bertouch JW. The road to consensus: considerations for the safe use and prescribing of COX-2-specific inhibitors. Med J Aust 2002; 176: 332-334. <MJA full text>
  • 2. The Australian COX-2 specific Inhibitor (CSI) Prescribing Group. Considerations for the safe prescribing and use of COX-2-specific inhibitors. Med J Aust 2002; 176: 328-331. <eMJA full text>
  • 3. Moynihan R, Heath I, Henry D. Selling sickness: the pharmaceutical industry and disease mongering. BMJ 2002; 324: 886-891.
  • 4. Healthy Skepticism <http://www.healthyskepticism.org>. Accessed 10 September 2002.
  • 5. US Food and Drug Administration. Celebrex capsules (celecoxib). NDA 20-998/S-009. Medical officer review. 20 September 2000. <http://www.fda.gov/ohrms/dockets/ac/01/briefing/3677b1_03_med.pdf>. Accessed 10 September 2002.
  • 6. Jüni P, Rutjes A, Dieppe P. Are selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs? BMJ 2002; 324: 1287-1288.
  • 7. Silverstein FE, Faich G, Reicin A, et al. Gastrointestinal toxicity with celecoxib versus nonsteroidal anti-inflammatory drugs for osteoarthritis — the CLASS study: a randomized controlled trial. JAMA 2000; 281: 1247-1255.
  • 8. Health Insurance Commission. Health Statistics. Pharmaceutical Benefits Scheme. <http://www.medicareaustralia.gov.au/providers/health_statistics/statistical_reporting/pbs.htm>. Accessed 10 September 2002, link updated Nov 2005.
  • 9. Graudins L. Celecoxib prescribing — drug use review in a Sydney teaching hospital. Quality Use of Medicines Mapping Project. <http://www.qummap.health.gov.au/plist.asp?project=988>. Accessed 10 September 2002.

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