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To the Editor: Although treatment with vitamin D has been shown to reduce hip fracture risk in elderly institutionalised people,1 there has been a perception that vitamin D deficiency is generally uncommon in countries with high sunlight exposure such as Australia.
We studied the prevalence of vitamin D deficiency in older people in residential aged-care facilities (hostels and nursing homes) in the northern Sydney area as part of the FREE study (Fracture Risk Epidemiology in the Elderly), a prospective study of fracture incidence in more than 2000 participants. Here, we report baseline serum 25(OH) vitamin D concentrations in the first 386 participants, determined in partially purified lipid extracts using a competitive protein binding assay.2
The sample comprised 252 women and 134 men (mean ± SE age, 86.7 ± 0.6 v 81.2 ± 0.7 years, respectively; P < 0.001). The mean serum 25(OH)D level was 17 nmol/L (SD, 12) and median serum 25(OH)D level was 15 nmol/L (interquartile range, 9 to 22). Vitamin D deficiency (defined as a serum 25(OH)D concentration < 28 nmol/L) was present in 86% of women and 68% of men. There was no significant difference in serum vitamin D levels between women in nursing homes versus women in hostels, nor between men in nursing homes versus those in hostels. Although serum vitamin D levels were low throughout the year, a small rise was observed in summer (P < 0.01). Length of stay in the residential facility was not a predictor of serum vitamin D level. Mean parathyroid hormone levels were 93 pg/mL (normal range, 12–72 pg/mL) and rose when vitamin D levels dropped below 21 nmol/L, indicating secondary hyperparathyroidism.
A number of previous studies have suggested a high prevalence of vitamin D deficiency in older institutionalised Australians in southern States,2-4 but we are unaware of any published studies in Sydney (latitude 33°S). However, as the prevalence of vitamin D deficiency in older people living in the community in Geelong is low,5 our study suggests that factors like confinement indoors is more important than latitude.
Given the relationship between vitamin D status and fracture, with more than 72 500 nursing home residents and 60 200 hostel residents in Australia in 1997, our findings indicate that vitamin D deficiency represents a significant public health problem in elderly institutionalised Australians regardless of geographical location. Importantly, this problem could be solved relatively simply by measures such as a short period of daily sunlight exposure or giving moderate doses of vitamin D annually to nursing home and hostel residents.
Acknowledgements: This study was funded by a grant from the National Health and Medical Research Council.
University of Sydney, Sydney, NSW.
Philip N Sambrook, MD, FRACP, Professor of Rheumatology; Ian D Cameron, MB BS, PhD, FAFRM, Associate Professor, Rehabilitation Studies Unit; Robert G Cumming, MB BS, MPM, PhD, FAFPHM, Associate Professor, Department of Public Health and Community Medicine; Jennifer M Schwarz, BSc, FREE Study Coordinator, Institute of Bone and Joint Research; Angelika Trube, DMedTech, Senior Technical Officer, Department of Veterinary Sciences.Prince of Wales Medical Research Institute, Sydney, NSW.
Stephen R Lord, PhD, Associate Professor.Public Health Unit and Department of Rheumatology, Royal North Shore Hospital, Sydney, NSW.
Lynnette M March, PhD, FRACP, Associate Professor.Correspondence: Professor Philip N Sambrook, University of Sydney, Sydney, NSW 2006. sambrookATmed.usyd.edu.au
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©The Medical Journal of Australia 2002 www.mja.com.au PRINT ISSN: 0025-729X ONLINE ISSN: 1326-5377