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Vitamin D deficiency is common in frail institutionalised older people in northern Sydney

Philip N Sambrook, Ian D Cameron, Robert G Cumming, Stephen R Lord, Jennifer M Schwarz, Angelika Trube and Lynnette M March
MJA 2002; 176 (11): 560

To the Editor: Although treatment with vitamin D has been shown to reduce hip fracture risk in elderly institutionalised people,1 there has been a perception that vitamin D deficiency is generally uncommon in countries with high sunlight exposure such as Australia.

We studied the prevalence of vitamin D deficiency in older people in residential aged-care facilities (hostels and nursing homes) in the northern Sydney area as part of the FREE study (Fracture Risk Epidemiology in the Elderly), a prospective study of fracture incidence in more than 2000 participants. Here, we report baseline serum 25(OH) vitamin D concentrations in the first 386 participants, determined in partially purified lipid extracts using a competitive protein binding assay.2

The sample comprised 252 women and 134 men (mean ± SE age, 86.7 ± 0.6 v 81.2 ± 0.7 years, respectively; P < 0.001). The mean serum 25(OH)D level was 17 nmol/L (SD, 12) and median serum 25(OH)D level was 15 nmol/L (interquartile range, 9 to 22). Vitamin D deficiency (defined as a serum 25(OH)D concentration < 28 nmol/L) was present in 86% of women and 68% of men. There was no significant difference in serum vitamin D levels between women in nursing homes versus women in hostels, nor between men in nursing homes versus those in hostels. Although serum vitamin D levels were low throughout the year, a small rise was observed in summer (P < 0.01). Length of stay in the residential facility was not a predictor of serum vitamin D level. Mean parathyroid hormone levels were 93 pg/mL (normal range, 12–72 pg/mL) and rose when vitamin D levels dropped below 21 nmol/L, indicating secondary hyperparathyroidism.

A number of previous studies have suggested a high prevalence of vitamin D deficiency in older institutionalised Australians in southern States,2-4 but we are unaware of any published studies in Sydney (latitude 33°S). However, as the prevalence of vitamin D deficiency in older people living in the community in Geelong is low,5 our study suggests that factors like confinement indoors is more important than latitude.

Given the relationship between vitamin D status and fracture, with more than 72 500 nursing home residents and 60 200 hostel residents in Australia in 1997, our findings indicate that vitamin D deficiency represents a significant public health problem in elderly institutionalised Australians regardless of geographical location. Importantly, this problem could be solved relatively simply by measures such as a short period of daily sunlight exposure or giving moderate doses of vitamin D annually to nursing home and hostel residents.

Acknowledgements: This study was funded by a grant from the National Health and Medical Research Council.

  1. Chapuy MC, Arlot ME, Duboeuf F, et al. Vitamin D3 and calcium to prevent hip fractures in elderly women. New Engl J Med 1992; 327: 1637-1642. <PubMed>
  2. Du X, Greenfield H, David DR, et al. Vitamin D deficiency and associated factors in adolescent girls in Beijing. Am J Clin Nutr 2001; 74: 494-500. <PubMed>
  3. Stein M, Wark JD, Scherer SC, et al. Falls relate to vitamin D and parathyroid hormone in an Australian nursing home and hostel. J Am Ger Soc 1999; 47: 1195-1201.
  4. Inderjeeth CA, Niklason F, Al-Lahham Y, et al. Vitamin D deficiency and secondary hyperparathyroidism: clinical and biochemical associations in older non-institutionalised southern Tasmanians. Aust N Z J Med 2000; 30: 209-214. <PubMed>
  5. Pasco JA, Henry MJ, Nicholson GC, et al. Vitamin D status of women in the Geelong Osteoporosis Study: association with diet and casual exposure to sunlight. Med J Aust 2001; 175: 401-405. <PubMed>

(Received 21 Mar 2002, accepted 26 Mar 2002)

University of Sydney, Sydney, NSW.

Philip N Sambrook, MD, FRACP, Professor of Rheumatology; Ian D Cameron, MB BS, PhD, FAFRM, Associate Professor, Rehabilitation Studies Unit; Robert G Cumming, MB BS, MPM, PhD, FAFPHM, Associate Professor, Department of Public Health and Community Medicine; Jennifer M Schwarz, BSc, FREE Study Coordinator, Institute of Bone and Joint Research; Angelika Trube, DMedTech, Senior Technical Officer, Department of Veterinary Sciences.

Prince of Wales Medical Research Institute, Sydney, NSW.

Stephen R Lord, PhD, Associate Professor.

Public Health Unit and Department of Rheumatology, Royal North Shore Hospital, Sydney, NSW.

Lynnette M March, PhD, FRACP, Associate Professor.

Correspondence: Professor Philip N Sambrook, University of Sydney, Sydney, NSW 2006. sambrookATmed.usyd.edu.au

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©The Medical Journal of Australia 2002 www.mja.com.au PRINT ISSN: 0025-729X ONLINE ISSN: 1326-5377